Synthesis of a novel tetrafluoropyridine-containing amino acid and tripeptide

Alex S. Hudson; Alex Hoose; Christopher R. Coxon; Graham Sandford; Steven L. Cobb

doi:10.1016/j.tetlet.2013.06.124

Synthesis of a novel tetrafluoropyridine-containing amino acid and tripeptide

Alex S. Hudson
, Alex Hoose
, Christopher R. Coxon
, Graham Sandford
, Steven L. Cobb^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The synthesis of a novel fluoropyridine-containing amino acid from pentafluoropyridine by a nucleophilic substitution process is reported. The orthogonal protecting groups can be manipulated and the fluoropyridine amino acid incorporated into a tripeptide.

Original language	English
Pages (from-to)	4865-4867
Number of pages	3
Journal	Tetrahedron Letters
Volume	54
Issue number	36
DOIs	https://doi.org/10.1016/j.tetlet.2013.06.124
Publication status	Published - 4 Sept 2013

Keywords

Novel amino acid
Pentafluoropyridine
Peptides

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2013.06.124

Cite this

@article{6b5589c0f2a24505a0f7551788238579,

title = "Synthesis of a novel tetrafluoropyridine-containing amino acid and tripeptide",

abstract = "The synthesis of a novel fluoropyridine-containing amino acid from pentafluoropyridine by a nucleophilic substitution process is reported. The orthogonal protecting groups can be manipulated and the fluoropyridine amino acid incorporated into a tripeptide.",

keywords = "Novel amino acid, Pentafluoropyridine, Peptides",

author = "Hudson, \{Alex S.\} and Alex Hoose and Coxon, \{Christopher R.\} and Graham Sandford and Cobb, \{Steven L.\}",

year = "2013",

month = sep,

day = "4",

doi = "10.1016/j.tetlet.2013.06.124",

language = "English",

volume = "54",

pages = "4865--4867",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "36",

}

TY - JOUR

T1 - Synthesis of a novel tetrafluoropyridine-containing amino acid and tripeptide

AU - Hudson, Alex S.

AU - Hoose, Alex

AU - Coxon, Christopher R.

AU - Sandford, Graham

AU - Cobb, Steven L.

PY - 2013/9/4

Y1 - 2013/9/4

N2 - The synthesis of a novel fluoropyridine-containing amino acid from pentafluoropyridine by a nucleophilic substitution process is reported. The orthogonal protecting groups can be manipulated and the fluoropyridine amino acid incorporated into a tripeptide.

AB - The synthesis of a novel fluoropyridine-containing amino acid from pentafluoropyridine by a nucleophilic substitution process is reported. The orthogonal protecting groups can be manipulated and the fluoropyridine amino acid incorporated into a tripeptide.

KW - Novel amino acid

KW - Pentafluoropyridine

KW - Peptides

UR - https://www.scopus.com/pages/publications/84881184221

U2 - 10.1016/j.tetlet.2013.06.124

DO - 10.1016/j.tetlet.2013.06.124

M3 - Article

AN - SCOPUS:84881184221

SN - 0040-4039

VL - 54

SP - 4865

EP - 4867

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 36

ER -

Synthesis of a novel tetrafluoropyridine-containing amino acid and tripeptide

Abstract

Keywords

ASJC Scopus subject areas

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