Synthesis of 6-aryl-2,4-diamino-pyrimidines and triazines using palladium catalysed Suzuki cross-coupling reactions

G. Cooke, H. Augier de Cremiers, V. M. Rotello, B. Tarbit, P. E. Vanderstraeten

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51 Citations (Scopus)

Abstract

The high yielding synthesis of 6-aryl-2,4-diaminopyrimidines and triazines via palladium catalysed Suzuki cross-coupling reactions of commercially available 6-chloro-2,4-diaminopyrimidine 1 or 6-chloro-2,4-diaminotriazine 8 and aryl boronic acids are described. © 2001 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2787-2789
Number of pages3
JournalTetrahedron
Volume57
Issue number14
DOIs
Publication statusPublished - 2 Apr 2001

Keywords

  • Pyrimidines
  • Suzuki cross-coupling
  • Tetrakis(triphenylphosphine)palladium
  • Triazines

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    Cooke, G., Augier de Cremiers, H., Rotello, V. M., Tarbit, B., & Vanderstraeten, P. E. (2001). Synthesis of 6-aryl-2,4-diamino-pyrimidines and triazines using palladium catalysed Suzuki cross-coupling reactions. Tetrahedron, 57(14), 2787-2789. https://doi.org/10.1016/S0040-4020(01)00119-3