Synthesis of α-heterosubstituted glycine derivatives from dihaloethanamides

Patrick D. Bailey; S. Richard Baker; Andrew N. Boa; Joanne Clayson; Georgina M. Rosair

Synthesis of α-heterosubstituted glycine derivatives from dihaloethanamides

Patrick D. Bailey, S. Richard Baker, Andrew N. Boa, Joanne Clayson, Georgina M. Rosair

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A range of protected a-heterosubstituted analogues of glycine were synthesised from starting materials of the type CHFX-CONHR [X = Cl, Br, I; R = CH₂Ph, (s)-CHMePh]; the final products included derivatives of glycine possessing N, O, F or S in the a-position, and the first example of a free a-fluoro-a-amino acid (a-fluorobetaine) whose structure was confirmed by X-ray crystal structure determination.

Original language	English
Pages (from-to)	7755-7758
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	42
Publication status	Published - 15 Oct 1998

Keywords

Amino acids and derivatives
Peptide analogues/mimetics

Cite this

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abstract = "A range of protected a-heterosubstituted analogues of glycine were synthesised from starting materials of the type CHFX-CONHR [X = Cl, Br, I; R = CH2Ph, (s)-CHMePh]; the final products included derivatives of glycine possessing N, O, F or S in the a-position, and the first example of a free a-fluoro-a-amino acid (a-fluorobetaine) whose structure was confirmed by X-ray crystal structure determination.",

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AU - Clayson, Joanne

AU - Rosair, Georgina M.

PY - 1998/10/15

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N2 - A range of protected a-heterosubstituted analogues of glycine were synthesised from starting materials of the type CHFX-CONHR [X = Cl, Br, I; R = CH2Ph, (s)-CHMePh]; the final products included derivatives of glycine possessing N, O, F or S in the a-position, and the first example of a free a-fluoro-a-amino acid (a-fluorobetaine) whose structure was confirmed by X-ray crystal structure determination.

AB - A range of protected a-heterosubstituted analogues of glycine were synthesised from starting materials of the type CHFX-CONHR [X = Cl, Br, I; R = CH2Ph, (s)-CHMePh]; the final products included derivatives of glycine possessing N, O, F or S in the a-position, and the first example of a free a-fluoro-a-amino acid (a-fluorobetaine) whose structure was confirmed by X-ray crystal structure determination.

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KW - Peptide analogues/mimetics

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IS - 42

ER -

Synthesis of α-heterosubstituted glycine derivatives from dihaloethanamides

Abstract

Keywords

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