Synthesis of α-aminophosphonic and α-aminophosphinic acids and derived dipeptides from 4-acetoxyazetidin-2-ones

Malcolm M Campbell, Nicholas Carruthers

Research output: Contribution to journalArticle

Abstract

4-Oxoazetidin-2-ylphosphonates and 4-oxoazetidin-2-ylphosphinates, obtained from the Arbusov reactions of 4-acetoxyazetidin-2-one and 4a-acetoxy- 3ß-phthalimidoazetidin-2-one with a variety of phosphites and phosphonites, were hydrolysed to ß-phosphono- and ß-phosphino-ß-alanine derivatives which were converted into alanyl dipeptides, conditions for the sequential removal of protecting groups for carboxylic acids, phosphonic acids, and amines were investigated.

Original languageEnglish
Pages (from-to)730-731
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number15
Publication statusPublished - 1980

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