Synthesis of α-aminophosphonic and α-aminophosphinic acids and derived dipeptides from 4-acetoxyazetidin-2-ones

Malcolm M Campbell, Nicholas Carruthers

Research output: Contribution to journalArticle

Abstract

4-Oxoazetidin-2-ylphosphonates and 4-oxoazetidin-2-ylphosphinates, obtained from the Arbusov reactions of 4-acetoxyazetidin-2-one and 4a-acetoxy- 3ß-phthalimidoazetidin-2-one with a variety of phosphites and phosphonites, were hydrolysed to ß-phosphono- and ß-phosphino-ß-alanine derivatives which were converted into alanyl dipeptides, conditions for the sequential removal of protecting groups for carboxylic acids, phosphonic acids, and amines were investigated.

Original languageEnglish
Pages (from-to)730-731
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number15
Publication statusPublished - 1980

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Phosphorous Acids
Phosphites
Dipeptides
Carboxylic Acids
Alanine
Amines
Derivatives
Acids

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issn = "0022-4936",
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Synthesis of α-aminophosphonic and α-aminophosphinic acids and derived dipeptides from 4-acetoxyazetidin-2-ones. / Campbell, Malcolm M; Carruthers, Nicholas.

In: Journal of the Chemical Society, Chemical Communications, No. 15, 1980, p. 730-731.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Campbell, Malcolm M

AU - Carruthers, Nicholas

PY - 1980

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M3 - Article

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JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

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