Synthesis, crystal structure and anti-malarial activity of novel spiro- 1,2,4,5-tetraoxacycloalkanes

Kaoru Tsuchiya, Yoshiaki Hamada, Araki Masuyama, Masatomo Nojima, Kevin J. McCullough, Hye Sook Kim, Yasuharu Shibata, Yusuke Wataya

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53 Citations (Scopus)

Abstract

(Cycloalkylidene)bishydroperoxides 3 react with 1,n-dihaloalkanes (n = 3-6) in the presence of CsOH-H2O in DMF affording the corresponding spiro- 1,2,4,5-tetraoxacycloalkanes 4 in moderate yields. Compound 4ba exhibits significant antimalarial activity in vitro against P. falciparum.

Original languageEnglish
Pages (from-to)4077-4080
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number21
DOIs
Publication statusPublished - 21 May 1999

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    Tsuchiya, K., Hamada, Y., Masuyama, A., Nojima, M., McCullough, K. J., Kim, H. S., Shibata, Y., & Wataya, Y. (1999). Synthesis, crystal structure and anti-malarial activity of novel spiro- 1,2,4,5-tetraoxacycloalkanes. Tetrahedron Letters, 40(21), 4077-4080. https://doi.org/10.1016/S0040-4039(99)00653-X