Synthesis, characterization, crystal structure, and DNA binding of two copper(II)-hydrazone complexes

Madshusudan Nandy; David L. Hughes; Georgina M. Rosair; Raj Kumar Bhubon Singh; Samiran Mitra

doi:10.1080/00958972.2014.964697

Synthesis, characterization, crystal structure, and DNA binding of two copper(II)-hydrazone complexes

Madshusudan Nandy^*, David L. Hughes, Georgina M. Rosair, Raj Kumar Bhubon Singh, Samiran Mitra

^*Corresponding author for this work

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Two new Cu(II)-hydrazone complexes, [Cu(L)(Hbpe)ClO₄]·ClO₄·[Cu(L)Cl] (1) and [Cu(HL)₂]·1.5ClO₄·0.5OH (2) (where HL = (E)-N'-(1-(pyridine-2-yl)ethylidene)benzohydrazide and bpe = trans-1-(2-pyridyl)-2-(4-pyridyl)ethylene), have been synthesized and characterized by physicochemical methods. The structures of the complexes have been established by single-crystal X-ray diffraction direct methods, which reveal that the metal ions have distorted square-pyramidal and square-planar geometries in 1, and a distorted octahedral geometry in 2. DNA binding of HL, 1, and 2, performed by UV-vis titration in tris-buffer medium, yielded binding constants, which are 9.5 × 10³, 1.88 × 10⁴, and 4.66 × 10⁴ M^-1, respectively. Viscosity measurements suggest a surface or groove-binding mode of interaction between CT-DNA with HL, 1, and 2.

Original language	English
Pages (from-to)	3335-3353
Number of pages	19
Journal	Journal of Coordination Chemistry
Volume	67
Issue number	20
DOIs	https://doi.org/10.1080/00958972.2014.964697
Publication status	Published - Oct 2014

Keywords

Copper(II)-hydrazone complex
Crystal structure
DNA binding
Electrochemistry
EPR

ASJC Scopus subject areas

Materials Chemistry
Physical and Theoretical Chemistry

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10.1080/00958972.2014.964697

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title = "Synthesis, characterization, crystal structure, and DNA binding of two copper(II)-hydrazone complexes",

abstract = "Two new Cu(II)-hydrazone complexes, [Cu(L)(Hbpe)ClO4]·ClO4·[Cu(L)Cl] (1) and [Cu(HL)2]·1.5ClO4·0.5OH (2) (where HL = (E)-N'-(1-(pyridine-2-yl)ethylidene)benzohydrazide and bpe = trans-1-(2-pyridyl)-2-(4-pyridyl)ethylene), have been synthesized and characterized by physicochemical methods. The structures of the complexes have been established by single-crystal X-ray diffraction direct methods, which reveal that the metal ions have distorted square-pyramidal and square-planar geometries in 1, and a distorted octahedral geometry in 2. DNA binding of HL, 1, and 2, performed by UV-vis titration in tris-buffer medium, yielded binding constants, which are 9.5 × 103, 1.88 × 104, and 4.66 × 104 M-1, respectively. Viscosity measurements suggest a surface or groove-binding mode of interaction between CT-DNA with HL, 1, and 2.",

keywords = "Copper(II)-hydrazone complex, Crystal structure, DNA binding, Electrochemistry, EPR",

author = "Madshusudan Nandy and Hughes, {David L.} and Rosair, {Georgina M.} and Singh, {Raj Kumar Bhubon} and Samiran Mitra",

year = "2014",

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doi = "10.1080/00958972.2014.964697",

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AU - Nandy, Madshusudan

AU - Hughes, David L.

AU - Rosair, Georgina M.

AU - Singh, Raj Kumar Bhubon

AU - Mitra, Samiran

PY - 2014/10

Y1 - 2014/10

N2 - Two new Cu(II)-hydrazone complexes, [Cu(L)(Hbpe)ClO4]·ClO4·[Cu(L)Cl] (1) and [Cu(HL)2]·1.5ClO4·0.5OH (2) (where HL = (E)-N'-(1-(pyridine-2-yl)ethylidene)benzohydrazide and bpe = trans-1-(2-pyridyl)-2-(4-pyridyl)ethylene), have been synthesized and characterized by physicochemical methods. The structures of the complexes have been established by single-crystal X-ray diffraction direct methods, which reveal that the metal ions have distorted square-pyramidal and square-planar geometries in 1, and a distorted octahedral geometry in 2. DNA binding of HL, 1, and 2, performed by UV-vis titration in tris-buffer medium, yielded binding constants, which are 9.5 × 103, 1.88 × 104, and 4.66 × 104 M-1, respectively. Viscosity measurements suggest a surface or groove-binding mode of interaction between CT-DNA with HL, 1, and 2.

AB - Two new Cu(II)-hydrazone complexes, [Cu(L)(Hbpe)ClO4]·ClO4·[Cu(L)Cl] (1) and [Cu(HL)2]·1.5ClO4·0.5OH (2) (where HL = (E)-N'-(1-(pyridine-2-yl)ethylidene)benzohydrazide and bpe = trans-1-(2-pyridyl)-2-(4-pyridyl)ethylene), have been synthesized and characterized by physicochemical methods. The structures of the complexes have been established by single-crystal X-ray diffraction direct methods, which reveal that the metal ions have distorted square-pyramidal and square-planar geometries in 1, and a distorted octahedral geometry in 2. DNA binding of HL, 1, and 2, performed by UV-vis titration in tris-buffer medium, yielded binding constants, which are 9.5 × 103, 1.88 × 104, and 4.66 × 104 M-1, respectively. Viscosity measurements suggest a surface or groove-binding mode of interaction between CT-DNA with HL, 1, and 2.

KW - Copper(II)-hydrazone complex

KW - Crystal structure

KW - DNA binding

KW - Electrochemistry

KW - EPR

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Synthesis, characterization, crystal structure, and DNA binding of two copper(II)-hydrazone complexes

Abstract

Keywords

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