Synthesis, characterization, crystal structure, and DNA binding of two copper(II)-hydrazone complexes

Madshusudan Nandy, David L. Hughes, Georgina M. Rosair, Raj Kumar Bhubon Singh, Samiran Mitra

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Two new Cu(II)-hydrazone complexes, [Cu(L)(Hbpe)ClO4]·ClO4·[Cu(L)Cl] (1) and [Cu(HL)2]·1.5ClO4·0.5OH (2) (where HL = (E)-N'-(1-(pyridine-2-yl)ethylidene)benzohydrazide and bpe = trans-1-(2-pyridyl)-2-(4-pyridyl)ethylene), have been synthesized and characterized by physicochemical methods. The structures of the complexes have been established by single-crystal X-ray diffraction direct methods, which reveal that the metal ions have distorted square-pyramidal and square-planar geometries in 1, and a distorted octahedral geometry in 2. DNA binding of HL, 1, and 2, performed by UV-vis titration in tris-buffer medium, yielded binding constants, which are 9.5 × 103, 1.88 × 104, and 4.66 × 104 M-1, respectively. Viscosity measurements suggest a surface or groove-binding mode of interaction between CT-DNA with HL, 1, and 2.

Original languageEnglish
Pages (from-to)3335-3353
Number of pages19
JournalJournal of Coordination Chemistry
Volume67
Issue number20
DOIs
Publication statusPublished - Oct 2014

Keywords

  • Copper(II)-hydrazone complex
  • Crystal structure
  • DNA binding
  • Electrochemistry
  • EPR

ASJC Scopus subject areas

  • Materials Chemistry
  • Physical and Theoretical Chemistry

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