Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...

Michael Devereux; Denis O'Shea; Mark O'Connor; Helen Grehan; Gavin Connor; Malachy McCann; Georgina Rosair; Fiona Lyng; Andrew Kellett; Maureen Walsh; Denise Egan; Bhumika Thati

doi:10.1016/j.poly.2007.05.006

Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...

Michael Devereux, Denis O'Shea, Mark O'Connor, Helen Grehan, Gavin Connor, Malachy McCann, Georgina Rosair, Fiona Lyng, Andrew Kellett, Maureen Walsh, Denise Egan, Bhumika Thati

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

136 Citations (Scopus)

Abstract

A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH₃COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2'-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)} nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)₂(bipy)(H₂O)] and the two square planar complexes [Cu(CH₃COO)₂ (5,6-DMBZDH)₂] and [Cu(salH)₂(BZDH)₂]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH₃COO)₂(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines. © 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	4073-4084
Number of pages	12
Journal	Polyhedron
Volume	26
Issue number	15
DOIs	https://doi.org/10.1016/j.poly.2007.05.006
Publication status	Published - 20 Sept 2007

Keywords

1,10-Phenanthroline
2,2′-Bipyridine
Benzimidazole
Catalase
Copper(II)carboxylates
SOD and anticancer activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.poly.2007.05.006

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Devereux, M., O'Shea, D., O'Connor, M., Grehan, H., Connor, G., McCann, M., Rosair, G., Lyng, F., Kellett, A., Walsh, M., Egan, D., & Thati, B. (2007). Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ... Polyhedron, 26(15), 4073-4084. https://doi.org/10.1016/j.poly.2007.05.006

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title = "Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...",

abstract = "A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH3COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2'-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)} nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)2(bipy)(H2O)] and the two square planar complexes [Cu(CH3COO)2 (5,6-DMBZDH)2] and [Cu(salH)2(BZDH)2]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH3COO)2(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines. {\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

keywords = "1,10-Phenanthroline, 2,2′-Bipyridine, Benzimidazole, Catalase, Copper(II)carboxylates, SOD and anticancer activity",

author = "Michael Devereux and Denis O'Shea and Mark O'Connor and Helen Grehan and Gavin Connor and Malachy McCann and Georgina Rosair and Fiona Lyng and Andrew Kellett and Maureen Walsh and Denise Egan and Bhumika Thati",

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doi = "10.1016/j.poly.2007.05.006",

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Devereux, M, O'Shea, D, O'Connor, M, Grehan, H, Connor, G, McCann, M, Rosair, G, Lyng, F, Kellett, A, Walsh, M, Egan, D & Thati, B 2007, 'Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...', Polyhedron, vol. 26, no. 15, pp. 4073-4084. https://doi.org/10.1016/j.poly.2007.05.006

TY - JOUR

T1 - Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands

T2 - ...

AU - Devereux, Michael

AU - O'Shea, Denis

AU - O'Connor, Mark

AU - Grehan, Helen

AU - Connor, Gavin

AU - McCann, Malachy

AU - Rosair, Georgina

AU - Lyng, Fiona

AU - Kellett, Andrew

AU - Walsh, Maureen

AU - Egan, Denise

AU - Thati, Bhumika

PY - 2007/9/20

Y1 - 2007/9/20

N2 - A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH3COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2'-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)} nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)2(bipy)(H2O)] and the two square planar complexes [Cu(CH3COO)2 (5,6-DMBZDH)2] and [Cu(salH)2(BZDH)2]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH3COO)2(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines. © 2007 Elsevier Ltd. All rights reserved.

AB - A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH3COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2'-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)} nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)2(bipy)(H2O)] and the two square planar complexes [Cu(CH3COO)2 (5,6-DMBZDH)2] and [Cu(salH)2(BZDH)2]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH3COO)2(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines. © 2007 Elsevier Ltd. All rights reserved.

KW - 1,10-Phenanthroline

KW - 2,2′-Bipyridine

KW - Benzimidazole

KW - Catalase

KW - Copper(II)carboxylates

KW - SOD and anticancer activity

UR - http://www.scopus.com/inward/record.url?scp=34548363729&partnerID=8YFLogxK

U2 - 10.1016/j.poly.2007.05.006

DO - 10.1016/j.poly.2007.05.006

M3 - Article

SN - 0277-5387

VL - 26

SP - 4073

EP - 4084

JO - Polyhedron

JF - Polyhedron

IS - 15

ER -

Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...

Abstract

Keywords

UN SDGs

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