Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...

Michael Devereux, Denis O'Shea, Mark O'Connor, Helen Grehan, Gavin Connor, Malachy McCann, Georgina Rosair, Fiona Lyng, Andrew Kellett, Maureen Walsh, Denise Egan, Bhumika Thati

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108 Citations (Scopus)

Abstract

A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH3COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2'-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)} nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)2(bipy)(H2O)] and the two square planar complexes [Cu(CH3COO)2 (5,6-DMBZDH)2] and [Cu(salH)2(BZDH)2]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH3COO)2(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines. © 2007 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)4073-4084
Number of pages12
JournalPolyhedron
Volume26
Issue number15
DOIs
Publication statusPublished - 20 Sep 2007

Keywords

  • 1,10-Phenanthroline
  • 2,2′-Bipyridine
  • Benzimidazole
  • Catalase
  • Copper(II)carboxylates
  • SOD and anticancer activity

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    Devereux, M., O'Shea, D., O'Connor, M., Grehan, H., Connor, G., McCann, M., Rosair, G., Lyng, F., Kellett, A., Walsh, M., Egan, D., & Thati, B. (2007). Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ... Polyhedron, 26(15), 4073-4084. https://doi.org/10.1016/j.poly.2007.05.006