Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

Nicola M. Howarth; W. Edward Lindsell; Euan Murray; Peter N. Preston

doi:10.1016/j.tetlet.2003.09.047

Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

Nicola M. Howarth, W. Edward Lindsell, Euan Murray, Peter N. Preston

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T₁₀ oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T₁₀-mer derivatives have been subsequently incorporated into polydiacetylene-containing liposomes. © 2003 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	8089-8092
Number of pages	4
Journal	Tetrahedron Letters
Volume	44
Issue number	44
DOIs	https://doi.org/10.1016/j.tetlet.2003.09.047
Publication status	Published - 27 Oct 2003

Keywords

Liposomes
Nucleic acid biosensors
PNA
Polydiacetylenes

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10.1016/j.tetlet.2003.09.047

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title = "Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid",

abstract = "The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T10 oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T10-mer derivatives have been subsequently incorporated into polydiacetylene-containing liposomes. {\textcopyright} 2003 Elsevier Ltd. All rights reserved.",

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author = "Howarth, \{Nicola M.\} and Lindsell, \{W. Edward\} and Euan Murray and Preston, \{Peter N.\}",

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T1 - Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

AU - Howarth, Nicola M.

AU - Lindsell, W. Edward

AU - Murray, Euan

AU - Preston, Peter N.

PY - 2003/10/27

Y1 - 2003/10/27

N2 - The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T10 oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T10-mer derivatives have been subsequently incorporated into polydiacetylene-containing liposomes. © 2003 Elsevier Ltd. All rights reserved.

AB - The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T10 oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T10-mer derivatives have been subsequently incorporated into polydiacetylene-containing liposomes. © 2003 Elsevier Ltd. All rights reserved.

KW - Liposomes

KW - Nucleic acid biosensors

KW - PNA

KW - Polydiacetylenes

UR - https://www.scopus.com/pages/publications/0141794220

U2 - 10.1016/j.tetlet.2003.09.047

DO - 10.1016/j.tetlet.2003.09.047

M3 - Article

VL - 44

SP - 8089

EP - 8092

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 44

ER -

Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

Abstract

Keywords

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