Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

Nicola M. Howarth, W. Edward Lindsell, Euan Murray, Peter N. Preston

Research output: Contribution to journalArticle

Abstract

The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T10 oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T10-mer derivatives have been subsequently incorporated into polydiacetylene-containing liposomes. © 2003 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)8089-8092
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number44
DOIs
Publication statusPublished - 27 Oct 2003

Fingerprint

Peptide Nucleic Acids
Thymine
Bearings (structural)
Polymerization
Acids
Cytosine
Adenine
Oligomers
Liposomes
Monomers
Derivatives
stearic acid
polydiacetylene

Keywords

  • Liposomes
  • Nucleic acid biosensors
  • PNA
  • Polydiacetylenes

Cite this

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Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid. / Howarth, Nicola M.; Lindsell, W. Edward; Murray, Euan; Preston, Peter N.

In: Tetrahedron Letters, Vol. 44, No. 44, 27.10.2003, p. 8089-8092.

Research output: Contribution to journalArticle

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