TY - JOUR
T1 - Synthesis and glycosidase inhibitory activity of 7-deoxycasuarine
AU - Carmona, AT
AU - Wightman, Richard
AU - Robina, I
AU - Vogel, P
PY - 2003
Y1 - 2003
N2 - Reaction of 1,4-anhydro-2,3,5-tri-O-benzyl-1-deoxy-1-imino-D-arabinitol N-oxide (8) with allyl alcohol produced a 3.6:1 mixture of the two pyrrolo[1,2-b]isoxazole derivatives 13 and 14. The major adduct 13 was converted to 7-deoxycasuarine (7), a potent, specific, and competitive inhibitor of amyloglucosidase from Rhizopus mold (see Table).
AB - Reaction of 1,4-anhydro-2,3,5-tri-O-benzyl-1-deoxy-1-imino-D-arabinitol N-oxide (8) with allyl alcohol produced a 3.6:1 mixture of the two pyrrolo[1,2-b]isoxazole derivatives 13 and 14. The major adduct 13 was converted to 7-deoxycasuarine (7), a potent, specific, and competitive inhibitor of amyloglucosidase from Rhizopus mold (see Table).
UR - http://www.scopus.com/inward/record.url?scp=0141989685&partnerID=8YFLogxK
U2 - 10.1002/hlca.200390248
DO - 10.1002/hlca.200390248
M3 - Article
SN - 1522-2675
VL - 86
SP - 3066
EP - 3073
JO - Helvetica Chimica Acta
JF - Helvetica Chimica Acta
IS - 9
ER -