Synthesis and characterization of water-soluble densely branched glycopolymers

Pol Besenius, Stacy Slavin, Filipe Vilela, David C. Sherrington

Research output: Contribution to journalArticle

Abstract

In a one-pot synthesis, highly branched synthetic glycopolymers have been prepared using the 'Strathclyde Methodology' involving a protected galactose monomethacrylate, a branching comonomer (ethylene glycol dimethacrylate or divinylbenzene) and a chain transfer agent (dodecanethiol) with 2,2'-azo-bis-isobutyronitrile as the source of radicals. Branching was confirmed via MALS/SEC and (l)H NMR spectroscopy. One attractive feature of the methodology employed is that in a single-step procedure highly branched polymers with molar masses over a range of two orders of magnitude were obtained by fine-tuning the composition of comonomer and chain transfer agent mole feed ratio. Deprotection of the isopropylidene galactose functionalities on the polymers was achieved, leading to water-soluble and potentially bio-compatible synthetic glycopolymers with branched main chain architecture. (c) 2008 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1524-1533
Number of pages10
JournalReactive and Functional Polymers
Volume68
Issue number11
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Conventional free-radical polymerisation
  • Branched architecture
  • Glycopolymer
  • Water-soluble copolymers
  • Facile synthesis
  • GLYCOSAMINOGLYCAN-MIMETIC BIOMATERIALS
  • TRANSFER RADICAL COPOLYMERIZATION
  • POLY(METHYL METHACRYLATE)S
  • HYPERBRANCHED GLYCOPOLYMERS
  • RAFT POLYMERIZATION
  • FACILE SYNTHESIS
  • POLYMERS
  • MONOMERS
  • POLYDISPERSITY
  • ARCHITECTURE

Cite this

Besenius, Pol ; Slavin, Stacy ; Vilela, Filipe ; Sherrington, David C. / Synthesis and characterization of water-soluble densely branched glycopolymers. In: Reactive and Functional Polymers. 2008 ; Vol. 68, No. 11. pp. 1524-1533.
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Synthesis and characterization of water-soluble densely branched glycopolymers. / Besenius, Pol; Slavin, Stacy; Vilela, Filipe; Sherrington, David C.

In: Reactive and Functional Polymers, Vol. 68, No. 11, 11.2008, p. 1524-1533.

Research output: Contribution to journalArticle

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T1 - Synthesis and characterization of water-soluble densely branched glycopolymers

AU - Besenius, Pol

AU - Slavin, Stacy

AU - Vilela, Filipe

AU - Sherrington, David C.

PY - 2008/11

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N2 - In a one-pot synthesis, highly branched synthetic glycopolymers have been prepared using the 'Strathclyde Methodology' involving a protected galactose monomethacrylate, a branching comonomer (ethylene glycol dimethacrylate or divinylbenzene) and a chain transfer agent (dodecanethiol) with 2,2'-azo-bis-isobutyronitrile as the source of radicals. Branching was confirmed via MALS/SEC and (l)H NMR spectroscopy. One attractive feature of the methodology employed is that in a single-step procedure highly branched polymers with molar masses over a range of two orders of magnitude were obtained by fine-tuning the composition of comonomer and chain transfer agent mole feed ratio. Deprotection of the isopropylidene galactose functionalities on the polymers was achieved, leading to water-soluble and potentially bio-compatible synthetic glycopolymers with branched main chain architecture. (c) 2008 Elsevier Ltd. All rights reserved.

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KW - POLYMERS

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