Synthesis and anti-HIV-1 activity of novel bicyclic nucleoside analogues restricted to an S-type conformation

Lisbet Kvsærnø, Claus Nielsen, Richard H. Wightman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

(1S,3R,4S)-3-Hydroxyrnethyl-1-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]hepta ne 9 and the corresponding cytosine derivative 10, nucleoside analogues with a novel bicyclic nucleoside structure 3, were synthesized in a few steps from the known 1-(3'-deoxy-ß-D-psicofuranosyl)uracil 4. NOE experiments verified the bicyclic nucleosides to be restricted to the expected S-type furanose conformation while the nucleobase is in an anti-conformation. Both nucleosides proved to be devoid of anti-HIV activity in MT-4 cells, which further supports the hypothesis that conformational flexibility of the furanose ring in a nucleoside analogue is necessary to obtain both intracellular 5'-triphosphorylation and inhibition of HIV-1 reverse transcriptase. © The Royal Society of Chemistry 2000.

Original languageEnglish
Pages (from-to)2903-2906
Number of pages4
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number17
DOIs
Publication statusPublished - 2000

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