Switching in of Ac-(Ala)10-NHMe at a solid surface

Mark J. Biggs; Milan Mijajlovic

doi:10.1016/j.nano.2008.03.008

Switching in of Ac-(Ala)₁₀-NHMe at a solid surface

Mark J. Biggs^*, Milan Mijajlovic

^*Corresponding author for this work

University Executive

Research output: Contribution to journal › Article › peer-review

Abstract

Using molecular simulation, we show how Ac-(Ala)₁₀-NHMe adsorbed on a solid surface switches between three conformations at distinct surface energies. The first switch is from an α-helix to a 3.1₁₀-helix. The second involves further stretching to a 2₇-helix. This switching has several potential applications including memory in molecular computers to motility elements in nanotechnology, and could be relevant to biological activity of proteins near solid surfaces (e.g., nano and aerosol particles) and disease processes induced by such interactions.

Original language	English
Pages (from-to)	262-265
Number of pages	4
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.nano.2008.03.008
Publication status	Published - Sept 2008

Keywords

Biomaterials
Molecular switches
Peptide
Protein function and disease
Protein structures

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
General Materials Science
Pharmaceutical Science

Access to Document

10.1016/j.nano.2008.03.008

Cite this

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abstract = "Using molecular simulation, we show how Ac-(Ala)10-NHMe adsorbed on a solid surface switches between three conformations at distinct surface energies. The first switch is from an α-helix to a 3.110-helix. The second involves further stretching to a 27-helix. This switching has several potential applications including memory in molecular computers to motility elements in nanotechnology, and could be relevant to biological activity of proteins near solid surfaces (e.g., nano and aerosol particles) and disease processes induced by such interactions.",

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