Switching in of Ac-(Ala)10-NHMe at a solid surface

Mark J. Biggs, Milan Mijajlovic

Research output: Contribution to journalArticle

Abstract

Using molecular simulation, we show how Ac-(Ala)10-NHMe adsorbed on a solid surface switches between three conformations at distinct surface energies. The first switch is from an α-helix to a 3.110-helix. The second involves further stretching to a 27-helix. This switching has several potential applications including memory in molecular computers to motility elements in nanotechnology, and could be relevant to biological activity of proteins near solid surfaces (e.g., nano and aerosol particles) and disease processes induced by such interactions.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume4
Issue number3
DOIs
Publication statusPublished - Sep 2008

Keywords

  • Biomaterials
  • Molecular switches
  • Peptide
  • Protein function and disease
  • Protein structures

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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