Switching in of Ac-(Ala)10-NHMe at a solid surface

Mark J. Biggs*, Milan Mijajlovic

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Using molecular simulation, we show how Ac-(Ala)10-NHMe adsorbed on a solid surface switches between three conformations at distinct surface energies. The first switch is from an α-helix to a 3.110-helix. The second involves further stretching to a 27-helix. This switching has several potential applications including memory in molecular computers to motility elements in nanotechnology, and could be relevant to biological activity of proteins near solid surfaces (e.g., nano and aerosol particles) and disease processes induced by such interactions.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Issue number3
Publication statusPublished - Sept 2008


  • Biomaterials
  • Molecular switches
  • Peptide
  • Protein function and disease
  • Protein structures

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • General Materials Science
  • Pharmaceutical Science


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