Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding

Simon R. Corrie, Germain J.P. Fernando, Michael L. Crichton, Marion E.G. Brunck, Chris D. Anderson, Mark A.F. Kendall

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Minimally invasive biosensors are of great interest for rapid detection of disease biomarkers for diagnostic screening at the point-of-care. Here we introduce a device which extracts disease-specific biomarkers directly from the upper dermis, without the needle and syringe or resource-intensive blood processing. Using antigen-specific antibodies raised in mice as a model system, we confirm the analytical specificity and sensitivity of the antibody capture and extraction in comparison to the conventional methods based on needle/syringe blood draw followed by processing and antigen-specific ELISAs.

Original languageEnglish
Pages (from-to)2655-2658
Number of pages4
JournalLab on a Chip
Volume10
Issue number20
DOIs
Publication statusPublished - 21 Oct 2010

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Biochemistry
  • Biomedical Engineering

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