Sub-picosecond laser ablation and plume mass spectrometry for the precision resection and diagnosis of soft biological tissue

Timothy P. Frazer; Rainer J. Beck; Ioannis Bitharas; Daniel Simon; Tatiana K. Malikova; Duncan C. Roberts; Andrew J. Moore; Lauren Ford; Zoltan Takats; Jonathan D. Shephard

doi:10.1117/12.3098486

Sub-picosecond laser ablation and plume mass spectrometry for the precision resection and diagnosis of soft biological tissue

Timothy P. Frazer^*
, Rainer J. Beck
, Ioannis Bitharas
, Daniel Simon
, Tatiana K. Malikova
, Duncan C. Roberts
, Andrew J. Moore
, Lauren Ford
, Zoltan Takats
, Jonathan D. Shephard^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

21 Downloads (Pure)

Abstract

Mass-spectrometry of biological tissue using sub-picosecond laser ablation is investigated experimentally. High relative abundances, including peaks at characteristic m/z, are observed across a range of laser parameters. Neuromorphic imaging is explored as a secondary diagnostic.

Original language	English
Title of host publication	Translational Biophotonics
Subtitle of host publication	Diagnostics and Therapeutics IV
Editors	Zhiwei Huang, Lothar D. Lilge
Publisher	SPIE
ISBN (Electronic)	9781510698062
ISBN (Print)	9781510698055
DOIs	https://doi.org/10.1117/12.3098486
Publication status	Published - 18 Dec 2025
Event	European Conferences on Biomedical Optics 2025 - Munich, Germany Duration: 22 Jun 2025 → 26 Jun 2025

Publication series

Name	Proceedings of SPIE
Volume	13934
ISSN (Print)	1605-7422
ISSN (Electronic)	2410-9045

Conference

Conference	European Conferences on Biomedical Optics 2025
Country/Territory	Germany
City	Munich
Period	22/06/25 → 26/06/25

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

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© 2025 Society of Photo-Optical Instrumentation Engineers (SPIE). Proceedings Volume 13934, Translational Biophotonics: Diagnostics and Therapeutics IV; 139342O (2025)
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Frazer, T. P., Beck, R. J., Bitharas, I., Simon, D., Malikova, T. K., Roberts, D. C., Moore, A. J., Ford, L., Takats, Z., & Shephard, J. D. (2025). Sub-picosecond laser ablation and plume mass spectrometry for the precision resection and diagnosis of soft biological tissue. In Z. Huang, & L. D. Lilge (Eds.), Translational Biophotonics: Diagnostics and Therapeutics IV Article 139342O (Proceedings of SPIE; Vol. 13934). SPIE. https://doi.org/10.1117/12.3098486

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title = "Sub-picosecond laser ablation and plume mass spectrometry for the precision resection and diagnosis of soft biological tissue",

abstract = "Mass-spectrometry of biological tissue using sub-picosecond laser ablation is investigated experimentally. High relative abundances, including peaks at characteristic m/z, are observed across a range of laser parameters. Neuromorphic imaging is explored as a secondary diagnostic.",

author = "Frazer, \{Timothy P.\} and Beck, \{Rainer J.\} and Ioannis Bitharas and Daniel Simon and Malikova, \{Tatiana K.\} and Roberts, \{Duncan C.\} and Moore, \{Andrew J.\} and Lauren Ford and Zoltan Takats and Shephard, \{Jonathan D.\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s); European Conferences on Biomedical Optics 2025 ; Conference date: 22-06-2025 Through 26-06-2025",

year = "2025",

month = dec,

day = "18",

doi = "10.1117/12.3098486",

language = "English",

isbn = "9781510698055",

series = "Proceedings of SPIE",

publisher = "SPIE",

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Frazer, TP , Beck, RJ , Bitharas, I, Simon, D, Malikova, TK, Roberts, DC, Moore, AJ, Ford, L, Takats, Z & Shephard, JD 2025, Sub-picosecond laser ablation and plume mass spectrometry for the precision resection and diagnosis of soft biological tissue. in Z Huang & LD Lilge (eds), Translational Biophotonics: Diagnostics and Therapeutics IV., 139342O, Proceedings of SPIE, vol. 13934, SPIE, European Conferences on Biomedical Optics 2025, Munich, Bavaria, Germany, 22/06/25. https://doi.org/10.1117/12.3098486

Sub-picosecond laser ablation and plume mass spectrometry for the precision resection and diagnosis of soft biological tissue. / Frazer, Timothy P.; Beck, Rainer J.; Bitharas, Ioannis et al.
Translational Biophotonics: Diagnostics and Therapeutics IV. ed. / Zhiwei Huang; Lothar D. Lilge. SPIE, 2025. 139342O (Proceedings of SPIE; Vol. 13934).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - Sub-picosecond laser ablation and plume mass spectrometry for the precision resection and diagnosis of soft biological tissue

AU - Frazer, Timothy P.

AU - Beck, Rainer J.

AU - Bitharas, Ioannis

AU - Simon, Daniel

AU - Malikova, Tatiana K.

AU - Roberts, Duncan C.

AU - Moore, Andrew J.

AU - Ford, Lauren

AU - Takats, Zoltan

AU - Shephard, Jonathan D.

PY - 2025/12/18

Y1 - 2025/12/18

N2 - Mass-spectrometry of biological tissue using sub-picosecond laser ablation is investigated experimentally. High relative abundances, including peaks at characteristic m/z, are observed across a range of laser parameters. Neuromorphic imaging is explored as a secondary diagnostic.

AB - Mass-spectrometry of biological tissue using sub-picosecond laser ablation is investigated experimentally. High relative abundances, including peaks at characteristic m/z, are observed across a range of laser parameters. Neuromorphic imaging is explored as a secondary diagnostic.

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DO - 10.1117/12.3098486

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SN - 9781510698055

T3 - Proceedings of SPIE

BT - Translational Biophotonics

A2 - Huang, Zhiwei

A2 - Lilge, Lothar D.

PB - SPIE

T2 - European Conferences on Biomedical Optics 2025

Y2 - 22 June 2025 through 26 June 2025

ER -

Sub-picosecond laser ablation and plume mass spectrometry for the precision resection and diagnosis of soft biological tissue

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