Study of mesoporous magnesium carbonate in contact with whole human blood

Sara Frykstrand, J. Forsgren, O. Cheung, P. Zhang, J. Hong, Maria Strømme, N. Ferraz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The interaction of mesoporours magnesium carbonate (Upsalite) particles (50-100 μm) with human whole blood was investigated using an in vitro loop model and the effect on the complement system, blood coagulation and red blood cell lysis was assessed. The removal of Ca2+ by Upsalite and the possible exchange with and/or release of Mg2+ were explored as well. Upsalite was found to present anticoagulant properties, most probably due to the uptake of Ca2+ by the particles. No hemolytic activity was detected at Upsalite concentrations up to 1 mg ml-1. Moderate to high levels of C3a and sC5b-9 were observed for Upsalite, however such levels were statistically different from the negative control only when the particle concentrations were 0.25 mg ml-1 and 1.0 mg ml-1, respectively. The presented findings are promising for the future development of mesoporous magnesium carbonate-based materials for biomedical applications.

Original languageEnglish
Pages (from-to)52810-52816
Number of pages7
JournalRSC Advances
Volume6
Issue number58
Early online date25 May 2016
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Study of mesoporous magnesium carbonate in contact with whole human blood'. Together they form a unique fingerprint.

  • Cite this

    Frykstrand, S., Forsgren, J., Cheung, O., Zhang, P., Hong, J., Strømme, M., & Ferraz, N. (2016). Study of mesoporous magnesium carbonate in contact with whole human blood. RSC Advances, 6(58), 52810-52816. https://doi.org/10.1039/c6ra05679b