Stimulation of IL-8 release from epithelial cells by gas cooker PM10: a pilot study

C. A J Dick, M. Dennekamp, S. Howarth, J. W. Cherrie, A. Seaton, K. Donaldson, A. Stone

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Objective - To measure the effect of matter collected by a method that has a 50% efficiency for particles with an aerodynamic diameter of 10 μm (PM10), generated by gas and electric cooking, on A549 epithelial cells with and without nitrogen dioxide (NO2). Method - Multiple indoor PM10 samples were collected on Teflon filters during the use of gas or electric cookers. Interleukin-8 (IL-8) concentrations were measured with a sandwich enzyme linked immunosorbent assay (ELISA) system. Results - Treatment of A549 cells with PM10 generated from gas cooking resulted in increased concentrations of IL-8 compared with untreated cells; particles from the electric cooker had no effect. NO2 did not alter the concentration of IL-8. Conclusion - PM10 generated by gas cooking has the potential to cause proinflammatory effects in lung cells. This may have implications for susceptible people.

    Original languageEnglish
    Pages (from-to)208-210
    Number of pages3
    JournalOccupational and Environmental Medicine
    Volume58
    Issue number3
    DOIs
    Publication statusPublished - 12 Mar 2001

    Keywords

    • Indoor air pollution
    • Interleukin-8
    • PM

    ASJC Scopus subject areas

    • Public Health, Environmental and Occupational Health
    • Environmental Science(all)

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