Stimulation and inhibition of synaptosome ATPases by noradrenaline. The involvement of cytoplasmic factor

John C Gilbert, A H Sawas, M. G. Wyllie

Research output: Contribution to journalArticle

Abstract

The activity of Na+, K+-ATPase was determined in synaptosomes and in pellets, (containing membranes, mitochondria and vesicles) and cytoplasm prepared from synaptosomes from rat cerebral cortex. The activity of the pellets was more than two fold higher than that of the synaptosomes or of their components and adding back the cytoplasm reduced the activity of the pellets. Noradrenaline did not affect the activity of the pellets but increased that of the synaptosomes in a dose-dependent fashion. It inhibited the activity of the membranes. Results indicate that synaptosomal Na+, K+-ATPase activity is low because of a factor in the cytoplasm and this factor is not present in synaptosome pellets. NA antagonises the activity of the factor.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalArchives Internationales de Pharmacodynamie et de Thérapie
Volume245
Issue number1
Publication statusPublished - 1980

Fingerprint Dive into the research topics of 'Stimulation and inhibition of synaptosome ATPases by noradrenaline. The involvement of cytoplasmic factor'. Together they form a unique fingerprint.

  • Cite this