Stereocontrol in asymmetric phospho-aldol catalysis. Chirality relaying in action

Tracy D Nixon, Scott J Dalgarno, Caroline V Ward, Mingliang Jiang, Malcolm A Halcrow, Colin A Kilner, Mark Thornton-Pett, Terence P Kee

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25 Citations (Scopus)

Abstract

The enantioselective addition of diorgano-H-phosphonates to aldehydes, the phospho-aldol reaction, is catalysed by both (R,R)-salcyen and (R,R)-salcyan complexes of aluminium at room temperature under aerobic conditions. However, whilst the former ligand system favours one absolute configuration of product alpha-hydroxyphosphonate ester, to the extent of
Original languageEnglish
Pages (from-to)809-821
Number of pages13
JournalComptes Rendus Chimie
Volume7
Issue number8-9
DOIs
Publication statusPublished - Aug 2004

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    Nixon, T. D., Dalgarno, S. J., Ward, C. V., Jiang, M., Halcrow, M. A., Kilner, C. A., Thornton-Pett, M., & Kee, T. P. (2004). Stereocontrol in asymmetric phospho-aldol catalysis. Chirality relaying in action. Comptes Rendus Chimie, 7(8-9), 809-821. https://doi.org/10.1016/j.crci.2003.10.020