Static response of coated microbubbles: Modeling simulations and parameter estimation

Alkmini Lytra; Nikos Pelekasis; Vassilis Sboros; Emmanouil Glynos; Vasileios Koutsos

doi:10.1016/j.piutam.2015.03.015

Static response of coated microbubbles: Modeling simulations and parameter estimation

Alkmini Lytra, Nikos Pelekasis^*, Vassilis Sboros, Emmanouil Glynos, Vasileios Koutsos

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The mechanical response of contrast agent microbubbles subject to a static load was investigated in force-deformation curves. Asymptotic relations are fitted with experimental AFM measurements of polymeric microbubbles available in the literature. The elastic modulus and shell thickness are estimated based on the transition from the classical linear (Reissner) to the nonlinear (Pogorelov) regime. The estimated value of the elastic modulus is in the order of GPa and the shell thickness in the order of nm, in good agreement with independent estimates. Numerical simulations recover the above transition and identify a third regime, dominated by the compressibility of the enclosed gas.

Original language	English
Pages (from-to)	123-133
Number of pages	11
Journal	Procedia IUTAM
Volume	16
DOIs	https://doi.org/10.1016/j.piutam.2015.03.015
Publication status	Published - 2015
Event	IUTAM Symposium on Dynamics of Capsules, Vesicles and Cells in Flow - Compiègne, France Duration: 15 Jul 2014 → 19 Jul 2014

Keywords

area dilatation
bending
bending modulus
gas compressibillity
shell thickness
stretching

ASJC Scopus subject areas

Mechanical Engineering

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10.1016/j.piutam.2015.03.015

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title = "Static response of coated microbubbles: Modeling simulations and parameter estimation",

abstract = "The mechanical response of contrast agent microbubbles subject to a static load was investigated in force-deformation curves. Asymptotic relations are fitted with experimental AFM measurements of polymeric microbubbles available in the literature. The elastic modulus and shell thickness are estimated based on the transition from the classical linear (Reissner) to the nonlinear (Pogorelov) regime. The estimated value of the elastic modulus is in the order of GPa and the shell thickness in the order of nm, in good agreement with independent estimates. Numerical simulations recover the above transition and identify a third regime, dominated by the compressibility of the enclosed gas.",

keywords = "area dilatation, bending, bending modulus, gas compressibillity, shell thickness, stretching",

author = "Alkmini Lytra and Nikos Pelekasis and Vassilis Sboros and Emmanouil Glynos and Vasileios Koutsos",

year = "2015",

doi = "10.1016/j.piutam.2015.03.015",

language = "English",

volume = "16",

pages = "123--133",

journal = "Procedia IUTAM",

issn = "2210-9838",

note = "IUTAM Symposium on Dynamics of Capsules, Vesicles and Cells in Flow ; Conference date: 15-07-2014 Through 19-07-2014",

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TY - JOUR

T1 - Static response of coated microbubbles

T2 - IUTAM Symposium on Dynamics of Capsules, Vesicles and Cells in Flow

AU - Lytra, Alkmini

AU - Pelekasis, Nikos

AU - Sboros, Vassilis

AU - Glynos, Emmanouil

AU - Koutsos, Vasileios

PY - 2015

Y1 - 2015

N2 - The mechanical response of contrast agent microbubbles subject to a static load was investigated in force-deformation curves. Asymptotic relations are fitted with experimental AFM measurements of polymeric microbubbles available in the literature. The elastic modulus and shell thickness are estimated based on the transition from the classical linear (Reissner) to the nonlinear (Pogorelov) regime. The estimated value of the elastic modulus is in the order of GPa and the shell thickness in the order of nm, in good agreement with independent estimates. Numerical simulations recover the above transition and identify a third regime, dominated by the compressibility of the enclosed gas.

AB - The mechanical response of contrast agent microbubbles subject to a static load was investigated in force-deformation curves. Asymptotic relations are fitted with experimental AFM measurements of polymeric microbubbles available in the literature. The elastic modulus and shell thickness are estimated based on the transition from the classical linear (Reissner) to the nonlinear (Pogorelov) regime. The estimated value of the elastic modulus is in the order of GPa and the shell thickness in the order of nm, in good agreement with independent estimates. Numerical simulations recover the above transition and identify a third regime, dominated by the compressibility of the enclosed gas.

KW - area dilatation

KW - bending

KW - bending modulus

KW - gas compressibillity

KW - shell thickness

KW - stretching

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DO - 10.1016/j.piutam.2015.03.015

M3 - Article

AN - SCOPUS:84946082260

SN - 2210-9838

VL - 16

SP - 123

EP - 133

JO - Procedia IUTAM

JF - Procedia IUTAM

Y2 - 15 July 2014 through 19 July 2014

ER -

Static response of coated microbubbles: Modeling simulations and parameter estimation

Abstract

Keywords

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