Análisis espectral de la coherencia cerebral en la enfermedad de Alzheimer

Translated title of the contribution: Spectral analysis of EEG coherence in Alzheimer's disease

P. L. Calderon, Mario Parra Rodriguez, Juan de Jesús Llibre Rodríguez, J. V. Gutierrez

    Research output: Contribution to journalArticle

    Abstract

    Introduction. In analysis of the electrical activity of the brain, coherence is a measure of the degree of synchrony between two or more regions of the brain with regard to their frequency values over a unit of time. Aims. To explore the functional alterations caused by Alzheimer's disease (AD), by evaluating the behaviour of coherence over the whole spectrum of EEG frequencies. Patients and methods. We studied a group of 42 patients with AD, according to criteria of the NINCDS-ADRDA group. Partial coherence (e.g. between two derivations each time) was calculated within and between hemispheres, during a state of mental rest; the Z statistic was also determined by comparing the coherence values with the standard data for age, sex and functional state of the brain. Results. Significantly low coherence values were obtained for the frontal-central regions of the left hemisphere (LH) and for the occipital-parietal regions of the right hemisphere (RH) in the delta band The same localisations were carried out for the theta band, in addition to the centrotemporal and temporal regions of the LH The highest incoherence values were observed for the alpha and beta bands, more specifically in frontal-central and occipital-parietal derivations of the RH, and temporal derivations of the LH. Conclusions. Non-activated partial coherence acts as an indicator of the degree of functional disconnection between brain regions in AD. Studying activated coherence in these patients could contribute new elements to our knowledge about the functional disorders observed in this disease.

    Original languageSpanish
    Pages (from-to)422-427
    Number of pages6
    JournalRevista de Neurologia
    Volume38
    Issue number5
    Publication statusPublished - 1 Mar 2004

    Fingerprint

    Electroencephalography
    Alzheimer Disease
    Brain
    Occipital Lobe
    Parietal Lobe
    Temporal Lobe

    Cite this

    Calderon, P. L., Parra Rodriguez, M., Llibre Rodríguez, J. D. J., & Gutierrez, J. V. (2004). Análisis espectral de la coherencia cerebral en la enfermedad de Alzheimer. Revista de Neurologia, 38(5), 422-427.
    Calderon, P. L. ; Parra Rodriguez, Mario ; Llibre Rodríguez, Juan de Jesús ; Gutierrez, J. V. / Análisis espectral de la coherencia cerebral en la enfermedad de Alzheimer. In: Revista de Neurologia. 2004 ; Vol. 38, No. 5. pp. 422-427.
    @article{1521156624684fd58bc274f520d16ef0,
    title = "An{\'a}lisis espectral de la coherencia cerebral en la enfermedad de Alzheimer",
    abstract = "Introduction. In analysis of the electrical activity of the brain, coherence is a measure of the degree of synchrony between two or more regions of the brain with regard to their frequency values over a unit of time. Aims. To explore the functional alterations caused by Alzheimer's disease (AD), by evaluating the behaviour of coherence over the whole spectrum of EEG frequencies. Patients and methods. We studied a group of 42 patients with AD, according to criteria of the NINCDS-ADRDA group. Partial coherence (e.g. between two derivations each time) was calculated within and between hemispheres, during a state of mental rest; the Z statistic was also determined by comparing the coherence values with the standard data for age, sex and functional state of the brain. Results. Significantly low coherence values were obtained for the frontal-central regions of the left hemisphere (LH) and for the occipital-parietal regions of the right hemisphere (RH) in the delta band The same localisations were carried out for the theta band, in addition to the centrotemporal and temporal regions of the LH The highest incoherence values were observed for the alpha and beta bands, more specifically in frontal-central and occipital-parietal derivations of the RH, and temporal derivations of the LH. Conclusions. Non-activated partial coherence acts as an indicator of the degree of functional disconnection between brain regions in AD. Studying activated coherence in these patients could contribute new elements to our knowledge about the functional disorders observed in this disease.",
    author = "Calderon, {P. L.} and {Parra Rodriguez}, Mario and {Llibre Rodr{\'i}guez}, {Juan de Jes{\'u}s} and Gutierrez, {J. V.}",
    year = "2004",
    month = "3",
    day = "1",
    language = "Spanish",
    volume = "38",
    pages = "422--427",
    journal = "Revista de Neurologia",
    issn = "0210-0010",
    publisher = "Revista de Neurologia",
    number = "5",

    }

    Calderon, PL, Parra Rodriguez, M, Llibre Rodríguez, JDJ & Gutierrez, JV 2004, 'Análisis espectral de la coherencia cerebral en la enfermedad de Alzheimer', Revista de Neurologia, vol. 38, no. 5, pp. 422-427.

    Análisis espectral de la coherencia cerebral en la enfermedad de Alzheimer. / Calderon, P. L.; Parra Rodriguez, Mario; Llibre Rodríguez, Juan de Jesús; Gutierrez, J. V.

    In: Revista de Neurologia, Vol. 38, No. 5, 01.03.2004, p. 422-427.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Análisis espectral de la coherencia cerebral en la enfermedad de Alzheimer

    AU - Calderon, P. L.

    AU - Parra Rodriguez, Mario

    AU - Llibre Rodríguez, Juan de Jesús

    AU - Gutierrez, J. V.

    PY - 2004/3/1

    Y1 - 2004/3/1

    N2 - Introduction. In analysis of the electrical activity of the brain, coherence is a measure of the degree of synchrony between two or more regions of the brain with regard to their frequency values over a unit of time. Aims. To explore the functional alterations caused by Alzheimer's disease (AD), by evaluating the behaviour of coherence over the whole spectrum of EEG frequencies. Patients and methods. We studied a group of 42 patients with AD, according to criteria of the NINCDS-ADRDA group. Partial coherence (e.g. between two derivations each time) was calculated within and between hemispheres, during a state of mental rest; the Z statistic was also determined by comparing the coherence values with the standard data for age, sex and functional state of the brain. Results. Significantly low coherence values were obtained for the frontal-central regions of the left hemisphere (LH) and for the occipital-parietal regions of the right hemisphere (RH) in the delta band The same localisations were carried out for the theta band, in addition to the centrotemporal and temporal regions of the LH The highest incoherence values were observed for the alpha and beta bands, more specifically in frontal-central and occipital-parietal derivations of the RH, and temporal derivations of the LH. Conclusions. Non-activated partial coherence acts as an indicator of the degree of functional disconnection between brain regions in AD. Studying activated coherence in these patients could contribute new elements to our knowledge about the functional disorders observed in this disease.

    AB - Introduction. In analysis of the electrical activity of the brain, coherence is a measure of the degree of synchrony between two or more regions of the brain with regard to their frequency values over a unit of time. Aims. To explore the functional alterations caused by Alzheimer's disease (AD), by evaluating the behaviour of coherence over the whole spectrum of EEG frequencies. Patients and methods. We studied a group of 42 patients with AD, according to criteria of the NINCDS-ADRDA group. Partial coherence (e.g. between two derivations each time) was calculated within and between hemispheres, during a state of mental rest; the Z statistic was also determined by comparing the coherence values with the standard data for age, sex and functional state of the brain. Results. Significantly low coherence values were obtained for the frontal-central regions of the left hemisphere (LH) and for the occipital-parietal regions of the right hemisphere (RH) in the delta band The same localisations were carried out for the theta band, in addition to the centrotemporal and temporal regions of the LH The highest incoherence values were observed for the alpha and beta bands, more specifically in frontal-central and occipital-parietal derivations of the RH, and temporal derivations of the LH. Conclusions. Non-activated partial coherence acts as an indicator of the degree of functional disconnection between brain regions in AD. Studying activated coherence in these patients could contribute new elements to our knowledge about the functional disorders observed in this disease.

    M3 - Article

    VL - 38

    SP - 422

    EP - 427

    JO - Revista de Neurologia

    JF - Revista de Neurologia

    SN - 0210-0010

    IS - 5

    ER -

    Calderon PL, Parra Rodriguez M, Llibre Rodríguez JDJ, Gutierrez JV. Análisis espectral de la coherencia cerebral en la enfermedad de Alzheimer. Revista de Neurologia. 2004 Mar 1;38(5):422-427.