Sodium acetate induces a metabolic alkalosis but not the increase in fatty acid oxidation observed following bicarbonate ingestion in humans

Gordon I. Smith, Asker E. Jeukendrup, Derek Ball

    Research output: Contribution to journalArticle

    Abstract

    We conducted this study to quantify the oxidation of exogenous acetate and to determine the effect of increased acetate availability upon fat and carbohydrate utilization in humans at rest. Eight healthy volunteers (6 males and 2 females) completed 2 separate trials, 7 d apart in a single-blind, randomized, crossover design. On each occasion, respiratory gas and arterialized venous blood samples were taken before and during 180 min following consumption of a drink containing either sodium acetate (NaAc) or NaHCO3 at a dose of 2 mmol/kg body mass. Labeled [1,2-13C] NaAc was added to the NaAc drink to quantify acetate oxidation. Both sodium salts induced a mild metabolic alkalosis and increased energy expenditure (P < 0.05) to a similar magnitude. NaHCO3 ingestion increased fat utilization from 587 ± 83 kJ/180 min to 693 ± 101 kJ/180 min (P = 0.01) with no change in carbohydrate utilization. Following ingestion of NaAc, the amount of fat and carbohydrate utilized did not differ from the preingestion values. However, oxidation of the exogenous acetate almost entirely (90%) replaced the additional fat that had been oxidized during the bicarbonate trial. We determined that 80.1 ± 2.3% of an exogenous source of acetate is oxidized in humans at rest. Whereas NaHCO3 ingestion increased fat oxidation, a similar response did not occur following NaAc ingestion despite the fact both sodium salts induced a similar increase in energy expenditure and shift in acid-base balance. © 2007 American Society for Nutrition.

    Original languageEnglish
    Pages (from-to)1750-1756
    Number of pages7
    JournalJournal of Nutrition
    Volume137
    Issue number7
    Publication statusPublished - Jul 2007

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    Sodium Acetate
    Alkalosis
    Bicarbonates
    Acetates
    Fatty Acids
    Eating
    Fats
    Carbohydrates
    Energy Metabolism
    Salts
    Sodium
    Acid-Base Equilibrium
    Cross-Over Studies
    Healthy Volunteers
    Gases

    Cite this

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    abstract = "We conducted this study to quantify the oxidation of exogenous acetate and to determine the effect of increased acetate availability upon fat and carbohydrate utilization in humans at rest. Eight healthy volunteers (6 males and 2 females) completed 2 separate trials, 7 d apart in a single-blind, randomized, crossover design. On each occasion, respiratory gas and arterialized venous blood samples were taken before and during 180 min following consumption of a drink containing either sodium acetate (NaAc) or NaHCO3 at a dose of 2 mmol/kg body mass. Labeled [1,2-13C] NaAc was added to the NaAc drink to quantify acetate oxidation. Both sodium salts induced a mild metabolic alkalosis and increased energy expenditure (P < 0.05) to a similar magnitude. NaHCO3 ingestion increased fat utilization from 587 ± 83 kJ/180 min to 693 ± 101 kJ/180 min (P = 0.01) with no change in carbohydrate utilization. Following ingestion of NaAc, the amount of fat and carbohydrate utilized did not differ from the preingestion values. However, oxidation of the exogenous acetate almost entirely (90{\%}) replaced the additional fat that had been oxidized during the bicarbonate trial. We determined that 80.1 ± 2.3{\%} of an exogenous source of acetate is oxidized in humans at rest. Whereas NaHCO3 ingestion increased fat oxidation, a similar response did not occur following NaAc ingestion despite the fact both sodium salts induced a similar increase in energy expenditure and shift in acid-base balance. {\circledC} 2007 American Society for Nutrition.",
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    Sodium acetate induces a metabolic alkalosis but not the increase in fatty acid oxidation observed following bicarbonate ingestion in humans. / Smith, Gordon I.; Jeukendrup, Asker E.; Ball, Derek.

    In: Journal of Nutrition, Vol. 137, No. 7, 07.2007, p. 1750-1756.

    Research output: Contribution to journalArticle

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