Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector

Nathan R Gemmell, Aongus McCarthy, Baochang Liu, Michael G Tanner, Sander D Dorenbos, Valery Zwiller, Michael S Patterson, Gerald S Buller, Brian C Wilson, Robert H Hadfield

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)
173 Downloads (Pure)

Abstract

Direct monitoring of singlet oxygen (¹O2) luminescence is a particularly challenging infrared photodetection problem. ¹O2, an excited state of the oxygen molecule, is a crucial intermediate in many biological processes. We employ a low noise superconducting nanowire single-photon detector to record ¹O2 luminescence at 1270 nm wavelength from a model photosensitizer (Rose Bengal) in solution. Narrow band spectral filtering and chemical quenching is used to verify the ¹O2 signal, and lifetime evolution with the addition of protein is studied. Furthermore, we demonstrate the detection of ¹O2 luminescence through a single optical fiber, a marked advance for dose monitoring in clinical treatments such as photodynamic therapy.
Original languageEnglish
Pages (from-to)5005-5013
Number of pages9
JournalOptics Express
Volume21
Issue number4
DOIs
Publication statusPublished - 25 Feb 2013

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