Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector

Nathan R Gemmell, Aongus McCarthy, Baochang Liu, Michael G Tanner, Sander D Dorenbos, Valery Zwiller, Michael S Patterson, Gerald S Buller, Brian C Wilson, Robert H Hadfield

Research output: Contribution to journalArticle

Abstract

Direct monitoring of singlet oxygen (¹O2) luminescence is a particularly challenging infrared photodetection problem. ¹O2, an excited state of the oxygen molecule, is a crucial intermediate in many biological processes. We employ a low noise superconducting nanowire single-photon detector to record ¹O2 luminescence at 1270 nm wavelength from a model photosensitizer (Rose Bengal) in solution. Narrow band spectral filtering and chemical quenching is used to verify the ¹O2 signal, and lifetime evolution with the addition of protein is studied. Furthermore, we demonstrate the detection of ¹O2 luminescence through a single optical fiber, a marked advance for dose monitoring in clinical treatments such as photodynamic therapy.
Original languageEnglish
Pages (from-to)5005-5013
Number of pages9
JournalOptics Express
Volume21
Issue number4
DOIs
Publication statusPublished - 25 Feb 2013

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Nanowires
Singlet Oxygen
Luminescence
Photons
Biological Phenomena
Optical Fibers
Rose Bengal
Photosensitizing Agents
Photochemotherapy
Noise
Oxygen
Proteins
Therapeutics

Cite this

Gemmell, Nathan R ; McCarthy, Aongus ; Liu, Baochang ; Tanner, Michael G ; Dorenbos, Sander D ; Zwiller, Valery ; Patterson, Michael S ; Buller, Gerald S ; Wilson, Brian C ; Hadfield, Robert H. / Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector. In: Optics Express. 2013 ; Vol. 21, No. 4. pp. 5005-5013.
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Gemmell, NR, McCarthy, A, Liu, B, Tanner, MG, Dorenbos, SD, Zwiller, V, Patterson, MS, Buller, GS, Wilson, BC & Hadfield, RH 2013, 'Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector', Optics Express, vol. 21, no. 4, pp. 5005-5013. https://doi.org/10.1364/OE.21.005005

Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector. / Gemmell, Nathan R; McCarthy, Aongus; Liu, Baochang; Tanner, Michael G; Dorenbos, Sander D; Zwiller, Valery; Patterson, Michael S; Buller, Gerald S; Wilson, Brian C; Hadfield, Robert H.

In: Optics Express, Vol. 21, No. 4, 25.02.2013, p. 5005-5013.

Research output: Contribution to journalArticle

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T1 - Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector

AU - Gemmell, Nathan R

AU - McCarthy, Aongus

AU - Liu, Baochang

AU - Tanner, Michael G

AU - Dorenbos, Sander D

AU - Zwiller, Valery

AU - Patterson, Michael S

AU - Buller, Gerald S

AU - Wilson, Brian C

AU - Hadfield, Robert H

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Y1 - 2013/2/25

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AB - Direct monitoring of singlet oxygen (¹O2) luminescence is a particularly challenging infrared photodetection problem. ¹O2, an excited state of the oxygen molecule, is a crucial intermediate in many biological processes. We employ a low noise superconducting nanowire single-photon detector to record ¹O2 luminescence at 1270 nm wavelength from a model photosensitizer (Rose Bengal) in solution. Narrow band spectral filtering and chemical quenching is used to verify the ¹O2 signal, and lifetime evolution with the addition of protein is studied. Furthermore, we demonstrate the detection of ¹O2 luminescence through a single optical fiber, a marked advance for dose monitoring in clinical treatments such as photodynamic therapy.

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