Single step microfluidic production of microbubble architechtures for hydrophobic drug delivery

Adam H. Churchman; Victoria Mico; Sally A. Peyman; Stephen D. Evans

Single step microfluidic production of microbubble architechtures for hydrophobic drug delivery

Adam H. Churchman, Victoria Mico, Sally A. Peyman, Stephen D. Evans^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Microbubbles (MBs) are micron-sized gas cores commonly encapsulated in a lipid monolayer. The compressibility of their gas core provides them with exceptional ultrasound (US) properties, and makes them suitable as US contrast agents. Flow focused (FF) microfluidics has proven to be a reliable technique for MB production, providing great control over their size and concentration. MBs have shown their ability to act as functional vehicles for drug transport and specific release. Oil phase incorporation to the MB architecture provides them with the ability to transport hydrophobic drugs and control the release, increasing drug proficiency, reducing the doses and also improving patient experience.

Original language	English
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2014
Publisher	Chemical and Biological Microsystems Society
Pages	1265-1267
Number of pages	3
ISBN (Electronic)	9780979806476
Publication status	Published - 2014
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2014 - San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014

Conference

Conference	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2014
Abbreviated title	MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	26/10/14 → 30/10/14

Keywords

Drug delivery
Microbubble

ASJC Scopus subject areas

Control and Systems Engineering

Cite this

@inproceedings{9fdee77a1fa14edaae465973d7ce817c,

title = "Single step microfluidic production of microbubble architechtures for hydrophobic drug delivery",

abstract = "Microbubbles (MBs) are micron-sized gas cores commonly encapsulated in a lipid monolayer. The compressibility of their gas core provides them with exceptional ultrasound (US) properties, and makes them suitable as US contrast agents. Flow focused (FF) microfluidics has proven to be a reliable technique for MB production, providing great control over their size and concentration. MBs have shown their ability to act as functional vehicles for drug transport and specific release. Oil phase incorporation to the MB architecture provides them with the ability to transport hydrophobic drugs and control the release, increasing drug proficiency, reducing the doses and also improving patient experience.",

keywords = "Drug delivery, Microbubble",

author = "Churchman, {Adam H.} and Victoria Mico and Peyman, {Sally A.} and Evans, {Stephen D.}",

note = "Publisher Copyright: {\textcopyright} 14CBMS.; 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2014, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

year = "2014",

language = "English",

pages = "1265--1267",

booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2014",

publisher = "Chemical and Biological Microsystems Society",

}

Churchman, AH, Mico, V, Peyman, SA & Evans, SD 2014, Single step microfluidic production of microbubble architechtures for hydrophobic drug delivery. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2014. Chemical and Biological Microsystems Society, pp. 1265-1267, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2014, San Antonio, Texas, United States, 26/10/14.

Single step microfluidic production of microbubble architechtures for hydrophobic drug delivery. / Churchman, Adam H.; Mico, Victoria; Peyman, Sally A. et al.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2014. Chemical and Biological Microsystems Society, 2014. p. 1265-1267.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Single step microfluidic production of microbubble architechtures for hydrophobic drug delivery

AU - Churchman, Adam H.

AU - Mico, Victoria

AU - Peyman, Sally A.

AU - Evans, Stephen D.

PY - 2014

Y1 - 2014

N2 - Microbubbles (MBs) are micron-sized gas cores commonly encapsulated in a lipid monolayer. The compressibility of their gas core provides them with exceptional ultrasound (US) properties, and makes them suitable as US contrast agents. Flow focused (FF) microfluidics has proven to be a reliable technique for MB production, providing great control over their size and concentration. MBs have shown their ability to act as functional vehicles for drug transport and specific release. Oil phase incorporation to the MB architecture provides them with the ability to transport hydrophobic drugs and control the release, increasing drug proficiency, reducing the doses and also improving patient experience.

AB - Microbubbles (MBs) are micron-sized gas cores commonly encapsulated in a lipid monolayer. The compressibility of their gas core provides them with exceptional ultrasound (US) properties, and makes them suitable as US contrast agents. Flow focused (FF) microfluidics has proven to be a reliable technique for MB production, providing great control over their size and concentration. MBs have shown their ability to act as functional vehicles for drug transport and specific release. Oil phase incorporation to the MB architecture provides them with the ability to transport hydrophobic drugs and control the release, increasing drug proficiency, reducing the doses and also improving patient experience.

KW - Drug delivery

KW - Microbubble

UR - http://www.scopus.com/inward/record.url?scp=84941712437&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84941712437

SP - 1265

EP - 1267

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

Single step microfluidic production of microbubble architechtures for hydrophobic drug delivery

Abstract

Conference

Keywords

ASJC Scopus subject areas

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