Single microbubble response using pulse sequences: Initial results

D. H. Thomas, M. B. Butler, T. Anderson, R. Steel, S. D. Pye, M. Poland, T. Brock-Fisher, W. N. McDicken, V. Sboros

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Abstract

The study of acoustic scattering by single microbubbles has the potential to offer improved signal processing techniques. A microacoustic system that employs a hydrodynamically-focused flow was used to detect radiofrequency (RF) backscatter from single microbubbles. RF data were collected using a commercial scanner. Results are presented for two agents, namely Definity (R) (Lantheus Medical Imaging, N. Billerica, MA, USA) and biSphere (R) (Point Biomedical Corp, San Carlos, CA, USA).The agents were insonified with amplitude-modulated pulses, and it was observed in both agents that a subpopulation of microbubbles did not produce a measurable echo from the first-half amplitude pulse, but did produce a response from the full amplitude pulse and from a subsequent half amplitude pulse. The number of microbubbles in this subpopulation was seen to increase with increasing transmit amplitude. These results do not bear out the simple theory of microbubble-pulse sequence interaction and invite a reassessment of signal processing approaches.

Original languageEnglish
Pages (from-to)112-119
Number of pages8
JournalUltrasound in Medicine and Biology
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2009

Cite this

Thomas, D. H., Butler, M. B., Anderson, T., Steel, R., Pye, S. D., Poland, M., Brock-Fisher, T., McDicken, W. N., & Sboros, V. (2009). Single microbubble response using pulse sequences: Initial results. Ultrasound in Medicine and Biology, 35(1), 112-119. https://doi.org/10.1016/j.ultrasmedbio.2008.07.006