Single cell deformation in shear and inertia dominant flow regimes

Fern J. Armistead; Julia Gala de Pablo; Hermes Gadêlha; Sally A. Peyman; Stephen D. Evans

Single cell deformation in shear and inertia dominant flow regimes

Fern J. Armistead
, Julia Gala de Pablo
, Hermes Gadêlha
, Sally A. Peyman^*
, Stephen D. Evans

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report new insight into cell deformability in inertia-dominant and shear-dominant flows. As a first model, we show that the deformability of HL60 cells changes with flow regime, which shows that flow regime can be used to probe different aspects of a cell's internal structure. Additionally, we show the importance of flow regime when using deformability to distinguish between primary (SW480) and secondary (SW620) colorectal cancer cell lines.

Original language	English
Title of host publication	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences 2017
Publisher	Chemical and Biological Microsystems Society
Pages	838-839
Number of pages	2
ISBN (Electronic)	9780692941836
Publication status	Published - 2020
Event	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences 2017 - Savannah, United States Duration: 22 Oct 2017 → 26 Oct 2017

Conference

Conference	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences 2017
Abbreviated title	MicroTAS 2017
Country/Territory	United States
City	Savannah
Period	22/10/17 → 26/10/17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cell mechanics
Deformability
Inertial-flow
Shear-flow
Single cells

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

@inproceedings{8ed6c4f206b24170865549dd4cd0d353,

title = "Single cell deformation in shear and inertia dominant flow regimes",

abstract = "We report new insight into cell deformability in inertia-dominant and shear-dominant flows. As a first model, we show that the deformability of HL60 cells changes with flow regime, which shows that flow regime can be used to probe different aspects of a cell's internal structure. Additionally, we show the importance of flow regime when using deformability to distinguish between primary (SW480) and secondary (SW620) colorectal cancer cell lines.",

keywords = "Cell mechanics, Deformability, Inertial-flow, Shear-flow, Single cells",

author = "Armistead, \{Fern J.\} and \{Gala de Pablo\}, Julia and Hermes Gad{\^e}lha and Peyman, \{Sally A.\} and Evans, \{Stephen D.\}",

note = "Publisher Copyright: {\textcopyright} 17CBMS-0001.; 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences 2017, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",

year = "2020",

language = "English",

pages = "838--839",

booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences 2017",

publisher = "Chemical and Biological Microsystems Society",

}

Armistead, FJ, Gala de Pablo, J, Gadêlha, H, Peyman, SA & Evans, SD 2020, Single cell deformation in shear and inertia dominant flow regimes. in 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences 2017. Chemical and Biological Microsystems Society, pp. 838-839, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences 2017, Savannah, Georgia, United States, 22/10/17.

Single cell deformation in shear and inertia dominant flow regimes. / Armistead, Fern J.; Gala de Pablo, Julia; Gadêlha, Hermes et al.
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences 2017. Chemical and Biological Microsystems Society, 2020. p. 838-839.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Single cell deformation in shear and inertia dominant flow regimes

AU - Armistead, Fern J.

AU - Gala de Pablo, Julia

AU - Gadêlha, Hermes

AU - Peyman, Sally A.

AU - Evans, Stephen D.

N1 - Publisher Copyright: © 17CBMS-0001.

PY - 2020

Y1 - 2020

N2 - We report new insight into cell deformability in inertia-dominant and shear-dominant flows. As a first model, we show that the deformability of HL60 cells changes with flow regime, which shows that flow regime can be used to probe different aspects of a cell's internal structure. Additionally, we show the importance of flow regime when using deformability to distinguish between primary (SW480) and secondary (SW620) colorectal cancer cell lines.

AB - We report new insight into cell deformability in inertia-dominant and shear-dominant flows. As a first model, we show that the deformability of HL60 cells changes with flow regime, which shows that flow regime can be used to probe different aspects of a cell's internal structure. Additionally, we show the importance of flow regime when using deformability to distinguish between primary (SW480) and secondary (SW620) colorectal cancer cell lines.

KW - Cell mechanics

KW - Deformability

KW - Inertial-flow

KW - Shear-flow

KW - Single cells

UR - https://www.scopus.com/pages/publications/85079601909

M3 - Conference contribution

AN - SCOPUS:85079601909

SP - 838

EP - 839

BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences 2017

PB - Chemical and Biological Microsystems Society

T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences 2017

Y2 - 22 October 2017 through 26 October 2017

ER -

Single cell deformation in shear and inertia dominant flow regimes

Abstract

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

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Cite this