Simultaneous determination of nafimidone [1-(2-naphthoylmethyl)imidazole], a new anticonvulsant agent, and a major metabolite in plasma by high-performance liquid chromatography

D. J M Graham, J. Eadie, B. M. Leadbetter, R. Metcalf

Research output: Contribution to journalArticle

Abstract

This paper describes two simple high-performance liquid chromatographic (HPLC) methods for the quantitation of nafimidone and its major metabolite in plasma. The methods employ UV and fluorescence detection, the latter involving wavelength switching to optimise sensitivity. The methods have been used to analyse plasma obtained following the administration of nafimidone hydrochloride to dog and monkey.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalJournal of Chromatography - Biomedical Applications
Volume275
Issue number1
Publication statusPublished - 1983

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