We report a silver-induced switching of regioselectivity in gold-catalyzed reactions, and we provide mechanistic evidence to suggest a true “silver effect”: that is, one that is implicated in the catalytic process itself, via σ-gold π-silver acetylides. These results are of significance because they clearly show that the use of silver as halide abstractors in gold-catalyzed reactions may result in “silver effects” when terminal alkyne substrates are involved.
- gold acetylide
ASJC Scopus subject areas
Veguillas, M., Rosair, G. M., Bebbington, M. W. P., & Lee, A-L. (2019). Silver Effect in Regiodivergent Gold-Catalyzed Hydroaminations. ACS Catalysis, 9(3), 2552-2557. https://doi.org/10.1021/acscatal.9b00249