Robust microbubble tracking for super resolution imaging in ultrasound

Kristoffer B. Hansen, Carlos A. Villagómez-Hoyos, Jens Christian Brasen, Konstantinos Diamantis, Vassilis Sboros, Charlotte Mehlin Sørensen, Jørgen Arendt Jensen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

18 Citations (Scopus)


Currently ultrasound resolution is limited by diffraction to approximately half the wavelength of the sound wave employed. In recent years, super resolution imaging techniques have overcome the diffraction limit through the localization and tracking of a sparse set of microbubbles through the vasculature. However, this has only been performed on fixated tissue, limiting its clinical application. This paper proposes a technique for making super resolution images on non-fixated tissue by first compensating for tissue movement and then tracking the individual microbubbles. The experiment is performed on the kidney of a anesthetized Sprage-Dawley rat by infusing SonoVue at 0.1× original concentration. The algorithm demonstrated in vivo that the motion compensation was capable of removing the movement caused by the mechanical ventilator. The results shows that microbubbles were localized with a higher precision, reducing the standard deviation of the super localizations from 22μm to 8 μm. The paper proves that the restriction of completely fixated tissue can be eliminated, when making super resolution imaging with microbubbles.

Original languageEnglish
Title of host publication2016 IEEE International Ultrasonics Symposium (IUS)
ISBN (Electronic)9781467398978
Publication statusPublished - 3 Nov 2016
Event2016 IEEE International Ultrasonics Symposium - VINCI Convention Center, Tours, France
Duration: 18 Sept 201621 Sept 2016

Publication series

NameIEEE International Ultrasonics Symposium : proceedings
ISSN (Print)1948-5727


Conference2016 IEEE International Ultrasonics Symposium
Abbreviated titleIUS 2016

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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