Robust microbubble tracking for super resolution imaging in ultrasound

Kristoffer B. Hansen, Carlos A. Villagómez-Hoyos, Jens Christian Brasen, Konstantinos Diamantis, Vassilis Sboros, Charlotte Mehlin Sørensen, Jørgen Arendt Jensen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

Currently ultrasound resolution is limited by diffraction to approximately half the wavelength of the sound wave employed. In recent years, super resolution imaging techniques have overcome the diffraction limit through the localization and tracking of a sparse set of microbubbles through the vasculature. However, this has only been performed on fixated tissue, limiting its clinical application. This paper proposes a technique for making super resolution images on non-fixated tissue by first compensating for tissue movement and then tracking the individual microbubbles. The experiment is performed on the kidney of a anesthetized Sprage-Dawley rat by infusing SonoVue at 0.1× original concentration. The algorithm demonstrated in vivo that the motion compensation was capable of removing the movement caused by the mechanical ventilator. The results shows that microbubbles were localized with a higher precision, reducing the standard deviation of the super localizations from 22μm to 8 μm. The paper proves that the restriction of completely fixated tissue can be eliminated, when making super resolution imaging with microbubbles.

Original languageEnglish
Title of host publication2016 IEEE International Ultrasonics Symposium (IUS)
PublisherIEEE
ISBN (Electronic)9781467398978
DOIs
Publication statusPublished - 3 Nov 2016
Event2016 IEEE International Ultrasonics Symposium - VINCI Convention Center, Tours, France
Duration: 18 Sep 201621 Sep 2016

Publication series

NameIEEE International Ultrasonics Symposium : proceedings
PublisherIEEE
ISSN (Print)1948-5727

Conference

Conference2016 IEEE International Ultrasonics Symposium
Abbreviated titleIUS 2016
CountryFrance
CityTours
Period18/09/1621/09/16

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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  • Cite this

    Hansen, K. B., Villagómez-Hoyos, C. A., Brasen, J. C., Diamantis, K., Sboros, V., Sørensen, C. M., & Jensen, J. A. (2016). Robust microbubble tracking for super resolution imaging in ultrasound. In 2016 IEEE International Ultrasonics Symposium (IUS) [7728793] (IEEE International Ultrasonics Symposium : proceedings). IEEE. https://doi.org/10.1109/ULTSYM.2016.7728793