Risk and protective factors for structural brain ageing in the eighth decade of life

Stuart J. Ritchie*, Elliot M. Tucker-Drob, Simon R. Cox, David Alexander Dickie, Maria Del C. Valdés Hernández, Janie Corley, Natalie A. Royle, Paul Redmond, Susana Muñoz Maniega, Alison Pattie, Benjamin S. Aribisala, Adele M. Taylor, Toni Kim Clarke, Alan J. Gow, John M. Starr, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Individuals differ markedly in brain structure, and in how this structure degenerates during ageing. In a large sample of human participants (baseline n = 731 at age 73 years; follow-up n = 488 at age 76 years), we estimated the magnitude of mean change and variability in changes in MRI measures of brain macrostructure (grey matter, white matter, and white matter hyperintensity volumes) and microstructure (fractional anisotropy and mean diffusivity from diffusion tensor MRI). All indices showed significant average change with age, with considerable heterogeneity in those changes. We then tested eleven socioeconomic, physical, health, cognitive, allostatic (inflammatory and metabolic), and genetic variables for their value in predicting these differences in changes. Many of these variables were significantly correlated with baseline brain structure, but few could account for significant portions of the heterogeneity in subsequent brain change. Physical fitness was an exception, being correlated both with brain level and changes. The results suggest that only a subset of correlates of brain structure are also predictive of differences in brain ageing.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalBrain Structure and Function
Publication statusPublished - 19 Apr 2017


  • Ageing
  • Genetic
  • Lifestyle
  • Longitudinal
  • Prediction
  • Structural MRI

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology


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