Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation

K. Roder; M. Schweizer

doi:10.1042/BST0351211

Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation

K. Roder, M. Schweizer

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A region of the rat FAS (fatty acid synthase) promoter has been defined as being responsible for RA (retinoic acid) responsiveness. The defined promoter region is devoid of canonical RA-response elements but contains cis-elements binding generalized and specific transcription factors that mediate the dietary response of FAS. Our results are consistent with SREBP-1c (sterol-regulatory- element-binding protein 1c) binding in this region, thus bringing about the RA responsiveness of the rat FAS proximal promoter. ©The Authors.

Original language	English
Pages (from-to)	1211-1214
Number of pages	4
Journal	Biochemical Society Transactions
Volume	35
Issue number	5
DOIs	https://doi.org/10.1042/BST0351211
Publication status	Published - Nov 2007

Keywords

Fatty acid synthase (FAS)
Liver X receptor (LXR)
Nuclear factor Y (NF-Y)
Retinoic acid receptor (RAR)
Retinoid X receptor (RXR)
Sterol-regulatory- element-binding protein 1 (SREBP-1)

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10.1042/BST0351211

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title = "Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation",

abstract = "A region of the rat FAS (fatty acid synthase) promoter has been defined as being responsible for RA (retinoic acid) responsiveness. The defined promoter region is devoid of canonical RA-response elements but contains cis-elements binding generalized and specific transcription factors that mediate the dietary response of FAS. Our results are consistent with SREBP-1c (sterol-regulatory- element-binding protein 1c) binding in this region, thus bringing about the RA responsiveness of the rat FAS proximal promoter. {\textcopyright}The Authors.",

keywords = "Fatty acid synthase (FAS), Liver X receptor (LXR), Nuclear factor Y (NF-Y), Retinoic acid receptor (RAR), Retinoid X receptor (RXR), Sterol-regulatory- element-binding protein 1 (SREBP-1)",

author = "K. Roder and M. Schweizer",

year = "2007",

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doi = "10.1042/BST0351211",

language = "English",

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T1 - Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation

AU - Roder, K.

AU - Schweizer, M.

PY - 2007/11

Y1 - 2007/11

N2 - A region of the rat FAS (fatty acid synthase) promoter has been defined as being responsible for RA (retinoic acid) responsiveness. The defined promoter region is devoid of canonical RA-response elements but contains cis-elements binding generalized and specific transcription factors that mediate the dietary response of FAS. Our results are consistent with SREBP-1c (sterol-regulatory- element-binding protein 1c) binding in this region, thus bringing about the RA responsiveness of the rat FAS proximal promoter. ©The Authors.

AB - A region of the rat FAS (fatty acid synthase) promoter has been defined as being responsible for RA (retinoic acid) responsiveness. The defined promoter region is devoid of canonical RA-response elements but contains cis-elements binding generalized and specific transcription factors that mediate the dietary response of FAS. Our results are consistent with SREBP-1c (sterol-regulatory- element-binding protein 1c) binding in this region, thus bringing about the RA responsiveness of the rat FAS proximal promoter. ©The Authors.

KW - Fatty acid synthase (FAS)

KW - Liver X receptor (LXR)

KW - Nuclear factor Y (NF-Y)

KW - Retinoic acid receptor (RAR)

KW - Retinoid X receptor (RXR)

KW - Sterol-regulatory- element-binding protein 1 (SREBP-1)

UR - https://www.scopus.com/pages/publications/36749045875

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DO - 10.1042/BST0351211

M3 - Article

C2 - 17956315

SN - 0300-5127

VL - 35

SP - 1211

EP - 1214

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 5

ER -

Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation

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