Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation

K. Roder, M. Schweizer

    Research output: Contribution to journalArticle

    Abstract

    A region of the rat FAS (fatty acid synthase) promoter has been defined as being responsible for RA (retinoic acid) responsiveness. The defined promoter region is devoid of canonical RA-response elements but contains cis-elements binding generalized and specific transcription factors that mediate the dietary response of FAS. Our results are consistent with SREBP-1c (sterol-regulatory- element-binding protein 1c) binding in this region, thus bringing about the RA responsiveness of the rat FAS proximal promoter. ©The Authors.

    Original languageEnglish
    Pages (from-to)1211-1214
    Number of pages4
    JournalBiochemical Society Transactions
    Volume35
    Issue number5
    DOIs
    Publication statusPublished - Nov 2007

    Fingerprint

    Sterol Regulatory Element Binding Protein 1
    Fatty Acid Synthases
    Tretinoin
    Response Elements
    Genetic Promoter Regions
    Protein Binding
    Transcription Factors

    Keywords

    • Fatty acid synthase (FAS)
    • Liver X receptor (LXR)
    • Nuclear factor Y (NF-Y)
    • Retinoic acid receptor (RAR)
    • Retinoid X receptor (RXR)
    • Sterol-regulatory- element-binding protein 1 (SREBP-1)

    Cite this

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    title = "Retinoic acid-mediated transcription and maturation of SREBP-1c regulates fatty acid synthase via cis-elements responsible for nutritional regulation",
    abstract = "A region of the rat FAS (fatty acid synthase) promoter has been defined as being responsible for RA (retinoic acid) responsiveness. The defined promoter region is devoid of canonical RA-response elements but contains cis-elements binding generalized and specific transcription factors that mediate the dietary response of FAS. Our results are consistent with SREBP-1c (sterol-regulatory- element-binding protein 1c) binding in this region, thus bringing about the RA responsiveness of the rat FAS proximal promoter. {\circledC}The Authors.",
    keywords = "Fatty acid synthase (FAS), Liver X receptor (LXR), Nuclear factor Y (NF-Y), Retinoic acid receptor (RAR), Retinoid X receptor (RXR), Sterol-regulatory- element-binding protein 1 (SREBP-1)",
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    AU - Schweizer, M.

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    KW - Nuclear factor Y (NF-Y)

    KW - Retinoic acid receptor (RAR)

    KW - Retinoid X receptor (RXR)

    KW - Sterol-regulatory- element-binding protein 1 (SREBP-1)

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