Retinal arteriolar geometry is associated with cerebral white matter hyperintensities on magnetic resonance imaging

Fergus N. Doubal, Rosemarie de Haan, Thomas J. MacGillivray, Petra E. Cohn-Hokke, Baljean Dhillon, Martin S. Dennis, Joanna M. Wardlaw

    Research output: Contribution to journalArticle

    Abstract

    Background Cerebral small vessel disease (lacunar stroke and cerebral white matter hyperintensities) is caused by vessel abnormalities of unknown aetiology. Retinal vessels show developmental and pathophysiological similarities to cerebral small vessels and microvessel geometry may influence vascular efficiency.

    Hypothesis Retinal arteriolar branching angles or coefficients (the ratio of the sum of the cross-sectional areas of the two daughter vessels to the cross-sectional area of the parent vessel at an arteriolar bifurcation) may be associated with cerebral small vessel disease.

    Methods We performed a cross-sectional observational study in a UK tertiary referral hospital. An experienced stroke physician recruited consecutive patients presenting with lacunar ischaemic stroke with a control group consisting of patients with minor cortical ischaemic stroke. We performed brain magnetic resonance imaging to assess the recent infarct and periventricular and deep white matter hyperintensities. We subtyped stroke with clinical and radiological findings. We took digital retinal photographs to assess retinal arteriolar branching coefficients and branching angles using a semi-automated technique.

    Results Two hundred and five patients were recruited (104 lacunar stroke, 101 cortical stroke), mean age 68-years (standard deviation 12). With multivariate analysis, increased branching coefficient was associated with periventricular white matter hyperintensities (P=0.006) and ischaemic heart disease (P<0.001), and decreased branching coefficient with deep white matter hyperintensities (P=0.003), but not with lacunar stroke subtype (P=0.96). We found no associations with retinal branching angles.

    Conclusions Retinal arteriolar geometry differs between cerebral small vessel phenotypes. Further research is needed to ascertain the clinical significance of these findings.

    Original languageEnglish
    Pages (from-to)434-439
    Number of pages6
    JournalInternational Journal of Stroke
    Volume5
    Issue number6
    DOIs
    Publication statusPublished - Dec 2010

    Cite this

    Doubal, F. N., de Haan, R., MacGillivray, T. J., Cohn-Hokke, P. E., Dhillon, B., Dennis, M. S., & Wardlaw, J. M. (2010). Retinal arteriolar geometry is associated with cerebral white matter hyperintensities on magnetic resonance imaging. International Journal of Stroke, 5(6), 434-439. https://doi.org/10.1111/j.1747-4949.2010.00483.x
    Doubal, Fergus N. ; de Haan, Rosemarie ; MacGillivray, Thomas J. ; Cohn-Hokke, Petra E. ; Dhillon, Baljean ; Dennis, Martin S. ; Wardlaw, Joanna M. / Retinal arteriolar geometry is associated with cerebral white matter hyperintensities on magnetic resonance imaging. In: International Journal of Stroke. 2010 ; Vol. 5, No. 6. pp. 434-439.
    @article{1a634716e20949b38bb2cf64da80b7ef,
    title = "Retinal arteriolar geometry is associated with cerebral white matter hyperintensities on magnetic resonance imaging",
    abstract = "Background Cerebral small vessel disease (lacunar stroke and cerebral white matter hyperintensities) is caused by vessel abnormalities of unknown aetiology. Retinal vessels show developmental and pathophysiological similarities to cerebral small vessels and microvessel geometry may influence vascular efficiency.Hypothesis Retinal arteriolar branching angles or coefficients (the ratio of the sum of the cross-sectional areas of the two daughter vessels to the cross-sectional area of the parent vessel at an arteriolar bifurcation) may be associated with cerebral small vessel disease.Methods We performed a cross-sectional observational study in a UK tertiary referral hospital. An experienced stroke physician recruited consecutive patients presenting with lacunar ischaemic stroke with a control group consisting of patients with minor cortical ischaemic stroke. We performed brain magnetic resonance imaging to assess the recent infarct and periventricular and deep white matter hyperintensities. We subtyped stroke with clinical and radiological findings. We took digital retinal photographs to assess retinal arteriolar branching coefficients and branching angles using a semi-automated technique.Results Two hundred and five patients were recruited (104 lacunar stroke, 101 cortical stroke), mean age 68-years (standard deviation 12). With multivariate analysis, increased branching coefficient was associated with periventricular white matter hyperintensities (P=0.006) and ischaemic heart disease (P<0.001), and decreased branching coefficient with deep white matter hyperintensities (P=0.003), but not with lacunar stroke subtype (P=0.96). We found no associations with retinal branching angles.Conclusions Retinal arteriolar geometry differs between cerebral small vessel phenotypes. Further research is needed to ascertain the clinical significance of these findings.",
    author = "Doubal, {Fergus N.} and {de Haan}, Rosemarie and MacGillivray, {Thomas J.} and Cohn-Hokke, {Petra E.} and Baljean Dhillon and Dennis, {Martin S.} and Wardlaw, {Joanna M.}",
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    language = "English",
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    Doubal, FN, de Haan, R, MacGillivray, TJ, Cohn-Hokke, PE, Dhillon, B, Dennis, MS & Wardlaw, JM 2010, 'Retinal arteriolar geometry is associated with cerebral white matter hyperintensities on magnetic resonance imaging', International Journal of Stroke, vol. 5, no. 6, pp. 434-439. https://doi.org/10.1111/j.1747-4949.2010.00483.x

    Retinal arteriolar geometry is associated with cerebral white matter hyperintensities on magnetic resonance imaging. / Doubal, Fergus N.; de Haan, Rosemarie; MacGillivray, Thomas J.; Cohn-Hokke, Petra E.; Dhillon, Baljean; Dennis, Martin S.; Wardlaw, Joanna M.

    In: International Journal of Stroke, Vol. 5, No. 6, 12.2010, p. 434-439.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Retinal arteriolar geometry is associated with cerebral white matter hyperintensities on magnetic resonance imaging

    AU - Doubal, Fergus N.

    AU - de Haan, Rosemarie

    AU - MacGillivray, Thomas J.

    AU - Cohn-Hokke, Petra E.

    AU - Dhillon, Baljean

    AU - Dennis, Martin S.

    AU - Wardlaw, Joanna M.

    PY - 2010/12

    Y1 - 2010/12

    N2 - Background Cerebral small vessel disease (lacunar stroke and cerebral white matter hyperintensities) is caused by vessel abnormalities of unknown aetiology. Retinal vessels show developmental and pathophysiological similarities to cerebral small vessels and microvessel geometry may influence vascular efficiency.Hypothesis Retinal arteriolar branching angles or coefficients (the ratio of the sum of the cross-sectional areas of the two daughter vessels to the cross-sectional area of the parent vessel at an arteriolar bifurcation) may be associated with cerebral small vessel disease.Methods We performed a cross-sectional observational study in a UK tertiary referral hospital. An experienced stroke physician recruited consecutive patients presenting with lacunar ischaemic stroke with a control group consisting of patients with minor cortical ischaemic stroke. We performed brain magnetic resonance imaging to assess the recent infarct and periventricular and deep white matter hyperintensities. We subtyped stroke with clinical and radiological findings. We took digital retinal photographs to assess retinal arteriolar branching coefficients and branching angles using a semi-automated technique.Results Two hundred and five patients were recruited (104 lacunar stroke, 101 cortical stroke), mean age 68-years (standard deviation 12). With multivariate analysis, increased branching coefficient was associated with periventricular white matter hyperintensities (P=0.006) and ischaemic heart disease (P<0.001), and decreased branching coefficient with deep white matter hyperintensities (P=0.003), but not with lacunar stroke subtype (P=0.96). We found no associations with retinal branching angles.Conclusions Retinal arteriolar geometry differs between cerebral small vessel phenotypes. Further research is needed to ascertain the clinical significance of these findings.

    AB - Background Cerebral small vessel disease (lacunar stroke and cerebral white matter hyperintensities) is caused by vessel abnormalities of unknown aetiology. Retinal vessels show developmental and pathophysiological similarities to cerebral small vessels and microvessel geometry may influence vascular efficiency.Hypothesis Retinal arteriolar branching angles or coefficients (the ratio of the sum of the cross-sectional areas of the two daughter vessels to the cross-sectional area of the parent vessel at an arteriolar bifurcation) may be associated with cerebral small vessel disease.Methods We performed a cross-sectional observational study in a UK tertiary referral hospital. An experienced stroke physician recruited consecutive patients presenting with lacunar ischaemic stroke with a control group consisting of patients with minor cortical ischaemic stroke. We performed brain magnetic resonance imaging to assess the recent infarct and periventricular and deep white matter hyperintensities. We subtyped stroke with clinical and radiological findings. We took digital retinal photographs to assess retinal arteriolar branching coefficients and branching angles using a semi-automated technique.Results Two hundred and five patients were recruited (104 lacunar stroke, 101 cortical stroke), mean age 68-years (standard deviation 12). With multivariate analysis, increased branching coefficient was associated with periventricular white matter hyperintensities (P=0.006) and ischaemic heart disease (P<0.001), and decreased branching coefficient with deep white matter hyperintensities (P=0.003), but not with lacunar stroke subtype (P=0.96). We found no associations with retinal branching angles.Conclusions Retinal arteriolar geometry differs between cerebral small vessel phenotypes. Further research is needed to ascertain the clinical significance of these findings.

    U2 - 10.1111/j.1747-4949.2010.00483.x

    DO - 10.1111/j.1747-4949.2010.00483.x

    M3 - Article

    VL - 5

    SP - 434

    EP - 439

    JO - International Journal of Stroke

    JF - International Journal of Stroke

    SN - 1747-4930

    IS - 6

    ER -