Dianin's compound (4-p-hydroxyphenyl- 2,2,4-trimethylchroman) has been resolved by crystallization of the (S)-(-)-camphanic esters (S, S)- and (R, S)- 4-(2,2,4- trimethylchroman4- yl) phenyl 4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1] heptane-1- carboxylate, both C28H32O5, from 2-methoxyethanol, yielding the pure S, S diastereomer. The relative stereochemistry of both diastereomers has been determined by X-ray crystallography, from which the absolute stereochemistry could be deduced from the known configuration of the camphanate moiety. The crystallographic conformations have been analysed, including the 1: 1 disorder of the R, S diastereomer.
|Number of pages||3|
|Journal||Acta Crystallographica Section C: Crystal Structure Communications|
|Publication status||Published - Jan 2005|