Remarkable Configurational Stability of Magnesiated Nitriles

Graeme Barker; Madeha R. Alshawish; Melanie C. Skilbeck; Iain Coldham

doi:10.1002/anie.201303442

Remarkable Configurational Stability of Magnesiated Nitriles

Graeme Barker, Madeha R. Alshawish, Melanie C. Skilbeck, Iain Coldham

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Quaternary stereocenters: Chiral α-magnesiated nitriles can be formed by deprotonation and are configurationally stable at low temperature, even for acyclic examples. These can be trapped with electrophiles to give enantiomerically enriched quaternary substituted products.

Original language	English
Pages (from-to)	7700-7703
Journal	Angewandte Chemie International Edition
Volume	52
Issue number	30
Early online date	19 Jun 2013
DOIs	https://doi.org/10.1002/anie.201303442
Publication status	Published - 22 Jul 2013

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title = "Remarkable Configurational Stability of Magnesiated Nitriles",

abstract = "Quaternary stereocenters: Chiral α-magnesiated nitriles can be formed by deprotonation and are configurationally stable at low temperature, even for acyclic examples. These can be trapped with electrophiles to give enantiomerically enriched quaternary substituted products.",

author = "Graeme Barker and Alshawish, {Madeha R.} and Skilbeck, {Melanie C.} and Iain Coldham",

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AU - Coldham, Iain

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AB - Quaternary stereocenters: Chiral α-magnesiated nitriles can be formed by deprotonation and are configurationally stable at low temperature, even for acyclic examples. These can be trapped with electrophiles to give enantiomerically enriched quaternary substituted products.

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JO - Angewandte Chemie International Edition

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Remarkable Configurational Stability of Magnesiated Nitriles

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