Remarkable Configurational Stability of Magnesiated Nitriles

Graeme Barker, Madeha R. Alshawish, Melanie C. Skilbeck, Iain Coldham

Research output: Contribution to journalArticle

Abstract

Quaternary stereocenters: Chiral α-magnesiated nitriles can be formed by deprotonation and are configurationally stable at low temperature, even for acyclic examples. These can be trapped with electrophiles to give enantiomerically enriched quaternary substituted products.
Original languageEnglish
Pages (from-to)7700-7703
JournalAngewandte Chemie International Edition
Volume52
Issue number30
Early online date19 Jun 2013
DOIs
Publication statusPublished - 22 Jul 2013

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