TY - JOUR
T1 - Regional gray matter volume is associated with rejection sensitivity
T2 - A voxel-based morphometry study
AU - Sun, Jiangzhou
AU - Li, Haijiang
AU - Li, Wenfu
AU - Wei, Dongtao
AU - Hitchman, Glenn
AU - Zhang, Qinglin
AU - Qiu, Jiang
N1 - Funding Information:
J.S. and H.L. contributed equally to this work. This study was supported by the National Natural Science Foundation of China (Grant Nos. 31070900, 30800293, 30970892, 31170983), the Program for New Century Excellent Talents in University (2011) by the Ministry of Education, the Fundamental Research Fund for the Central Universities (Grant Nos. SWU1209101, SWU1309466), China Postdoctoral Science Foundation funded Project No. 2012M510098, the Research Funds for Southwest University (SWU09103), the Key Discipline Fund of National 211 Project (Grant No. NSKD11007), and the postgraduate Innovation Foundation of Science and Technology of Southwest University (Grant No. kb2011002). The authors declare no conflicts of interest.
PY - 2014/9
Y1 - 2014/9
N2 - Rejection sensitivity (RS) can be defined as the disposition that one tends to anxiously expect, readily perceive, and intensely react to rejection. High-RS individuals are more likely to suffer mental disorders. Previous studies have investigated brain activity during social rejection using different kinds of rejection paradigms and have provided neural evidence of individual differences in response to rejection cues, but the association between individual differences in RS and brain structure has never been investigated. In this study, voxel-based morphometry (VBM) was used to investigate the relationship between gray matter volume (GMV) and RS in a large healthy sample of 150 men and 188 women. The participants completed the RS Questionnaire and underwent an anatomical magnetic resonance imaging scan. Multiple regression was used to analyze the correlation between regional GMV and RS scores, adjusting for age, sex, and total brain GMV. These results showed that GMV in the region of the posterior cingulate cortex/precuneus was negatively associated with RS, and GMV in the region of the inferior temporal gyrus was positively correlated with RS. These findings suggest a relationship between individual differences in RS and GMV in brain regions that are primarily related to social cognition.
AB - Rejection sensitivity (RS) can be defined as the disposition that one tends to anxiously expect, readily perceive, and intensely react to rejection. High-RS individuals are more likely to suffer mental disorders. Previous studies have investigated brain activity during social rejection using different kinds of rejection paradigms and have provided neural evidence of individual differences in response to rejection cues, but the association between individual differences in RS and brain structure has never been investigated. In this study, voxel-based morphometry (VBM) was used to investigate the relationship between gray matter volume (GMV) and RS in a large healthy sample of 150 men and 188 women. The participants completed the RS Questionnaire and underwent an anatomical magnetic resonance imaging scan. Multiple regression was used to analyze the correlation between regional GMV and RS scores, adjusting for age, sex, and total brain GMV. These results showed that GMV in the region of the posterior cingulate cortex/precuneus was negatively associated with RS, and GMV in the region of the inferior temporal gyrus was positively correlated with RS. These findings suggest a relationship between individual differences in RS and GMV in brain regions that are primarily related to social cognition.
KW - Posterior cingulate cortex/precuneus
KW - Rejection sensitivity
KW - Social cognition
KW - Voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=84905819014&partnerID=8YFLogxK
U2 - 10.3758/s13415-014-0249-z
DO - 10.3758/s13415-014-0249-z
M3 - Article
C2 - 24464638
AN - SCOPUS:84905819014
SN - 1530-7026
VL - 14
SP - 1077
EP - 1085
JO - Cognitive, Affective and Behavioral Neuroscience
JF - Cognitive, Affective and Behavioral Neuroscience
IS - 3
ER -