Regional gray matter volume and anxiety-related traits interact to predict somatic complaints in a non-clinical sample

Dongtao Wei, Xue Du, Wenfu Li, Qunlin Chen, Haijiang Li, Xin Hao, Lei Zhang, Glenn Hitchman, Qinglin Zhang, Jiang Qiu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Somatic complaints can be important features of an individual's expression of anxiety. Anxiety-related traits are also risk factors for somatic symptoms. However, it is not known which neuroanatomical mechanisms may be responsible for this relationship. In this study, our first step was to use voxel-based morphometry (VBM) approaches to investigate the neuroanatomical basis underlying somatic complaints in a large sample of healthy subjects. We found a significant positive correlation between somatic complaints and parahippocampal gyrus (PHG) volume adjacent to the entorhinal cortex. Further analysis revealed that the interaction between PHG volume/entorhinal cortex and neuroticism-anxiety (N-Anx) predicted somatic complaints. Specifically, somatic complaints were associated with higher N-Anx for individuals with increased PHG volume. These findings suggest that increased PHG volume and higher trait anxiety can predict vulnerability to somatic complaints in the general population.

Original languageEnglish
Pages (from-to)122-128
Number of pages7
JournalSocial Cognitive and Affective Neuroscience
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Anxiety
  • Neuroticism
  • Somatic complaints
  • Somatization
  • Voxel-based morphometry (VBM)

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

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