Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model

Richard L. Mort, Robert J H Ross, Kirsten J. Hainey, Olivia J. Harrison, Margaret A. Keighren, Gabriel Landini, Ruth E. Baker, Kevin J. Painter, Ian J. Jackson, Christian A. Yates

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Abstract

Bands of colour extending laterally from the dorsal to ventral trunk are a common feature of mouse chimeras. These stripes were originally taken as evidence of the directed dorsoventral migration of melanoblasts (the embryonic precursors of melanocytes) as they colonize the developing skin. Depigmented belly spots in mice with mutations in the receptor tyrosine kinase Kit are thought to represent a failure of this colonization, either due to impaired migration or proliferation. Tracing of single melanoblast clones, however, has revealed a diffuse distribution with high levels of axial mixing-hard to reconcile with directed migration. Here we construct an agent-based stochastic model calibrated by experimental measurements to investigate the formation of diffuse clones, chimeric stripes and belly spots. Our observations indicate that melanoblast colonization likely proceeds through a process of undirected migration, proliferation and tissue expansion, and that reduced proliferation is the cause of the belly spots in Kit mutants.

Original languageEnglish
Article number10288
JournalNature Communications
Volume7
DOIs
Publication statusPublished - 6 Jan 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

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    Mort, R. L., Ross, R. J. H., Hainey, K. J., Harrison, O. J., Keighren, M. A., Landini, G., Baker, R. E., Painter, K. J., Jackson, I. J., & Yates, C. A. (2016). Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. Nature Communications, 7, [10288]. https://doi.org/10.1038/ncomms10288