Recent advances in the field of peptide nucleic acids

Nicola M. Howarth

doi:10.2174/157017806778341852

Recent advances in the field of peptide nucleic acids

Nicola M. Howarth

School of Engineering & Physical Sciences

Research output: Contribution to journal › Literature review › peer-review

3 Citations (Scopus)

Abstract

Since their development, peptide nucleic acids (PNAs) have attracted much attention as potential pharmacological regulators of gene expression. Currently, applications of PNAs are restricted through deficiencies in target specificity, aqueous solubility and cellular uptake. This highlight reviews syntheses and hybridisation properties of recent PNA analogues designed to address these limitations. © 2006 Bentham Science Publishers Ltd.

Original language	English
Pages (from-to)	495-503
Number of pages	9
Journal	Letters in Organic Chemistry
Volume	3
Issue number	7
DOIs	https://doi.org/10.2174/157017806778341852
Publication status	Published - Jul 2006

Keywords

Backbone modifications
Hybridisation properties
Nucleobase modifications
Peptide nucleic acids
PNA analogues
Side chain modifications

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10.2174/157017806778341852

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AB - Since their development, peptide nucleic acids (PNAs) have attracted much attention as potential pharmacological regulators of gene expression. Currently, applications of PNAs are restricted through deficiencies in target specificity, aqueous solubility and cellular uptake. This highlight reviews syntheses and hybridisation properties of recent PNA analogues designed to address these limitations. © 2006 Bentham Science Publishers Ltd.

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KW - Hybridisation properties

KW - Nucleobase modifications

KW - Peptide nucleic acids

KW - PNA analogues

KW - Side chain modifications

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JO - Letters in Organic Chemistry

JF - Letters in Organic Chemistry

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Recent advances in the field of peptide nucleic acids

Abstract

Keywords

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