Recent advances in skin penetration enhancers for transdermal gene and drug delivery

Morteza Amjadi, Babak Mostaghaci, Metin Sitti

Research output: Contribution to journalReview article

Abstract

There is a growing interest in transdermal delivery systems because of their noninvasive, targeted, and on-demand delivery of gene and drugs. However, efficient penetration of therapeutic compounds into the skin is still challenging largely due to the impermeability of the outermost layer of the skin, known as stratum corneum. Recently, there have been major research activities to enhance the skin penetration depth of pharmacological agents. This article reviews recent advances in the development of various strategies for skin penetration enhancement. We show that approaches such as ultrasound waves, laser, and microneedle patches have successfully been employed to physically disrupt the stratum corneum structure for enhanced transdermal delivery. Rather than physical approaches, several non-physical route have also been utilized for efficient transdermal delivery across the skin barrier. Finally, we discuss some clinical applications of transdermal delivery systems for gene and drug delivery. This paper shows that transdermal delivery devices can potentially function for diverse healthcare and medical applications while further investigations are still necessary for more efficient skin penetration of gene and drugs.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalCurrent Gene Therapy
Volume17
Issue number2
DOIs
Publication statusPublished - 1 Apr 2017

Fingerprint

Skin
Pharmaceutical Preparations
Genes
Gene Transfer Techniques
Drug Delivery Systems
Cornea
Lasers
Pharmacology
Delivery of Health Care
Equipment and Supplies
Research
Therapeutics

Keywords

  • Gene and drug delivery
  • Skin barrier
  • Skin penetration enhancers
  • Transdermal delivery

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery
  • Genetics(clinical)

Cite this

Amjadi, Morteza ; Mostaghaci, Babak ; Sitti, Metin. / Recent advances in skin penetration enhancers for transdermal gene and drug delivery. In: Current Gene Therapy. 2017 ; Vol. 17, No. 2. pp. 139-146.
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Recent advances in skin penetration enhancers for transdermal gene and drug delivery. / Amjadi, Morteza; Mostaghaci, Babak; Sitti, Metin.

In: Current Gene Therapy, Vol. 17, No. 2, 01.04.2017, p. 139-146.

Research output: Contribution to journalReview article

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AB - There is a growing interest in transdermal delivery systems because of their noninvasive, targeted, and on-demand delivery of gene and drugs. However, efficient penetration of therapeutic compounds into the skin is still challenging largely due to the impermeability of the outermost layer of the skin, known as stratum corneum. Recently, there have been major research activities to enhance the skin penetration depth of pharmacological agents. This article reviews recent advances in the development of various strategies for skin penetration enhancement. We show that approaches such as ultrasound waves, laser, and microneedle patches have successfully been employed to physically disrupt the stratum corneum structure for enhanced transdermal delivery. Rather than physical approaches, several non-physical route have also been utilized for efficient transdermal delivery across the skin barrier. Finally, we discuss some clinical applications of transdermal delivery systems for gene and drug delivery. This paper shows that transdermal delivery devices can potentially function for diverse healthcare and medical applications while further investigations are still necessary for more efficient skin penetration of gene and drugs.

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