TY - JOUR
T1 - Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis
AU - Ziech, Dominique
AU - Franco, Rodrigo
AU - Pappa, Aglaia
AU - Panayiotidis, Mihalis I
PY - 2011/6/3
Y1 - 2011/6/3
N2 - Cancer is a multistage and complex process characterized by molecular alterations that underlie all three phases of its development: (i) initiation, (ii) promotion and (iii) progression. Some of these molecular events include alterations in gene expression that are regulated by both genetic and epigenetic mechanisms. On the other hand, “oxidative stress” implies a cellular state where ROS production exceeds the cell's ability to metabolize them resulting in excessive accumulation of ROS that overwhelms cellular defenses. Such state has been shown to regulate both genetic and epigenetic cascades underlying altered gene expression in human disease including cancer. Throughout this manuscript, we review the current state of knowledge on the role of ROS-induced oxidative stress in altering the genetic and epigenetic involvement during human carcinogenesis.
AB - Cancer is a multistage and complex process characterized by molecular alterations that underlie all three phases of its development: (i) initiation, (ii) promotion and (iii) progression. Some of these molecular events include alterations in gene expression that are regulated by both genetic and epigenetic mechanisms. On the other hand, “oxidative stress” implies a cellular state where ROS production exceeds the cell's ability to metabolize them resulting in excessive accumulation of ROS that overwhelms cellular defenses. Such state has been shown to regulate both genetic and epigenetic cascades underlying altered gene expression in human disease including cancer. Throughout this manuscript, we review the current state of knowledge on the role of ROS-induced oxidative stress in altering the genetic and epigenetic involvement during human carcinogenesis.
U2 - 10.1016/j.mrfmmm.2011.02.015
DO - 10.1016/j.mrfmmm.2011.02.015
M3 - Literature review
C2 - 21419141
VL - 711
SP - 167
EP - 173
JO - Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
IS - 1-2
ER -
