Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis

Dominique Ziech, Rodrigo Franco, Aglaia Pappa, Mihalis I Panayiotidis

    Research output: Contribution to journalLiterature review

    321 Citations (Scopus)

    Abstract

    Cancer is a multistage and complex process characterized by molecular alterations that underlie all three phases of its development: (i) initiation, (ii) promotion and (iii) progression. Some of these molecular events include alterations in gene expression that are regulated by both genetic and epigenetic mechanisms. On the other hand, “oxidative stress” implies a cellular state where ROS production exceeds the cell's ability to metabolize them resulting in excessive accumulation of ROS that overwhelms cellular defenses. Such state has been shown to regulate both genetic and epigenetic cascades underlying altered gene expression in human disease including cancer. Throughout this manuscript, we review the current state of knowledge on the role of ROS-induced oxidative stress in altering the genetic and epigenetic involvement during human carcinogenesis.
    Original languageEnglish
    Pages (from-to)167-173
    Number of pages6
    JournalMutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
    Volume711
    Issue number1-2
    DOIs
    Publication statusPublished - 3 Jun 2011

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