Since 2002 the discovery of a novel population of intrinsically photosensitive retinal ganglion cells, expressing the photopigment melanopsin, has attracted broad interest in human blue-light mediated non-visual effects including circadian regulation and cognitive function. Ageing is associated with insomnia and cognitive decline. It has been postulated that reduced blue-light transmission through the formation of cataract impairs melanopsin dependant non-visual brain responses mediated by intrinsically photosensitive retinal ganglion cells. We aimed to establish if any objective improvement in cognition could be demonstrated using a reaction time task (RTT) following cataract surgery and intraocular lens implantation.
Schmoll, C., Tendo, C., Aspinall, P., & Dhillon, B. (2011). Reaction time as a measure of enhanced blue-light mediated cognitive function following cataract surgery. British Journal of Ophthalmology, 95(12), 1656-9. https://doi.org/10.1136/bjophthalmol-2011-300677