Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication

R.P. Goodman, IAT Schaap, C.F. Tardin, C.M. Erben, R.M. Berry, C.F. Schmidt, A.J. Turberfield

Research output: Contribution to journalArticle

699 Citations (Scopus)

Abstract

Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.

Original languageEnglish
Pages (from-to)1661-1665
Number of pages5
JournalScience
Volume310
Issue number5754
DOIs
Publication statusPublished - 9 Dec 2005

Keywords

  • SINGLE-STRANDED-DNA
  • OCTAHEDRON
  • ELASTICITY
  • HELIX

Cite this

Goodman, R. P., Schaap, IAT., Tardin, C. F., Erben, C. M., Berry, R. M., Schmidt, C. F., & Turberfield, A. J. (2005). Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. Science, 310(5754), 1661-1665. https://doi.org/10.1126/science.1120367