Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication

R.P. Goodman; IAT Schaap; C.F. Tardin; C.M. Erben; R.M. Berry; C.F. Schmidt; A.J. Turberfield

doi:10.1126/science.1120367

Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication

R.P. Goodman, IAT Schaap, C.F. Tardin, C.M. Erben, R.M. Berry, C.F. Schmidt, A.J. Turberfield

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

881 Citations (Scopus)

Abstract

Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.

Original language	English
Pages (from-to)	1661-1665
Number of pages	5
Journal	Science
Volume	310
Issue number	5754
DOIs	https://doi.org/10.1126/science.1120367
Publication status	Published - 9 Dec 2005

Keywords

SINGLE-STRANDED-DNA
OCTAHEDRON
ELASTICITY
HELIX

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10.1126/science.1120367

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AU - Goodman, R.P.

AU - Schaap, IAT

AU - Tardin, C.F.

AU - Erben, C.M.

AU - Berry, R.M.

AU - Schmidt, C.F.

AU - Turberfield, A.J.

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AB - Practical components for three-dimensional molecular nanofabrication must be simple to produce, stereopure, rigid, and adaptable. We report a family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer. They can be connected by programmable DNA linkers. Their triangulated architecture confers structural stability; by compressing a DNA tetrahedron with an atomic force microscope, we have measured the axial compressibility of DNA and observed the buckling of the double helix under high loads.

KW - SINGLE-STRANDED-DNA

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KW - ELASTICITY

KW - HELIX

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JO - Science

JF - Science

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Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication

Abstract

Keywords

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