Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae

S. Vavassori, K. Wang, L. M. Schweizer, M. Schweizer

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    The model eukaryote Saccharomyces cerevisiae is well suited to investigate the causes of metabolic disturbance. PRPP [5-phospho-D-ribosyl-1(a)- pyrophosphate] may be regarded as a junction of carbon and nitrogen metabolism. As a result of this central position, perturbations in its synthesis can give rise to many unexpected cellular events, such as impaired cell integrity. We have taken advantage of S. cerevisiae's genetic tractability to investigate the metabolic links responsible for connecting the biochemical intermediate PRPP to apparently unrelated cellular functions. This approach provides insight into the co-ordination of different biological processes. ©2005 Biochemical Society.

    Original languageEnglish
    Pages (from-to)1418-1420
    Number of pages3
    JournalBiochemical Society Transactions
    Volume33
    Issue number6
    DOIs
    Publication statusPublished - Dec 2005

    Keywords

    • 5-phospho-D-ribosyl-1(α)- pyrophosphate synthetase (Prs)
    • Cell integrity
    • Metabolic networking
    • Rim11
    • Saccharomyces cerevisiae
    • Yeast two-hybrid interaction

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