Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae

S. Vavassori; K. Wang; L. M. Schweizer; M. Schweizer

doi:10.1042/BST20051418

Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae

S. Vavassori, K. Wang, L. M. Schweizer, M. Schweizer

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The model eukaryote Saccharomyces cerevisiae is well suited to investigate the causes of metabolic disturbance. PRPP [5-phospho-D-ribosyl-1(a)- pyrophosphate] may be regarded as a junction of carbon and nitrogen metabolism. As a result of this central position, perturbations in its synthesis can give rise to many unexpected cellular events, such as impaired cell integrity. We have taken advantage of S. cerevisiae's genetic tractability to investigate the metabolic links responsible for connecting the biochemical intermediate PRPP to apparently unrelated cellular functions. This approach provides insight into the co-ordination of different biological processes. ©2005 Biochemical Society.

Original language	English
Pages (from-to)	1418-1420
Number of pages	3
Journal	Biochemical Society Transactions
Volume	33
Issue number	6
DOIs	https://doi.org/10.1042/BST20051418
Publication status	Published - Dec 2005

Keywords

5-phospho-D-ribosyl-1(α)- pyrophosphate synthetase (Prs)
Cell integrity
Metabolic networking
Rim11
Saccharomyces cerevisiae
Yeast two-hybrid interaction

Access to Document

10.1042/BST20051418

Fingerprint Dive into the research topics of 'Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae'. Together they form a unique fingerprint.

Cite this

@article{64bfae0281264c7eab05af0cd1e1e6ab,

title = "Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae",

abstract = "The model eukaryote Saccharomyces cerevisiae is well suited to investigate the causes of metabolic disturbance. PRPP [5-phospho-D-ribosyl-1(a)- pyrophosphate] may be regarded as a junction of carbon and nitrogen metabolism. As a result of this central position, perturbations in its synthesis can give rise to many unexpected cellular events, such as impaired cell integrity. We have taken advantage of S. cerevisiae's genetic tractability to investigate the metabolic links responsible for connecting the biochemical intermediate PRPP to apparently unrelated cellular functions. This approach provides insight into the co-ordination of different biological processes. {\textcopyright}2005 Biochemical Society.",

keywords = "5-phospho-D-ribosyl-1(α)- pyrophosphate synthetase (Prs), Cell integrity, Metabolic networking, Rim11, Saccharomyces cerevisiae, Yeast two-hybrid interaction",

author = "S. Vavassori and K. Wang and Schweizer, {L. M.} and M. Schweizer",

year = "2005",

month = dec,

doi = "10.1042/BST20051418",

language = "English",

volume = "33",

pages = "1418--1420",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press Ltd.",

number = "6",

}

TY - JOUR

T1 - Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae

AU - Vavassori, S.

AU - Wang, K.

AU - Schweizer, L. M.

AU - Schweizer, M.

PY - 2005/12

Y1 - 2005/12

N2 - The model eukaryote Saccharomyces cerevisiae is well suited to investigate the causes of metabolic disturbance. PRPP [5-phospho-D-ribosyl-1(a)- pyrophosphate] may be regarded as a junction of carbon and nitrogen metabolism. As a result of this central position, perturbations in its synthesis can give rise to many unexpected cellular events, such as impaired cell integrity. We have taken advantage of S. cerevisiae's genetic tractability to investigate the metabolic links responsible for connecting the biochemical intermediate PRPP to apparently unrelated cellular functions. This approach provides insight into the co-ordination of different biological processes. ©2005 Biochemical Society.

AB - The model eukaryote Saccharomyces cerevisiae is well suited to investigate the causes of metabolic disturbance. PRPP [5-phospho-D-ribosyl-1(a)- pyrophosphate] may be regarded as a junction of carbon and nitrogen metabolism. As a result of this central position, perturbations in its synthesis can give rise to many unexpected cellular events, such as impaired cell integrity. We have taken advantage of S. cerevisiae's genetic tractability to investigate the metabolic links responsible for connecting the biochemical intermediate PRPP to apparently unrelated cellular functions. This approach provides insight into the co-ordination of different biological processes. ©2005 Biochemical Society.

KW - 5-phospho-D-ribosyl-1(α)- pyrophosphate synthetase (Prs)

KW - Cell integrity

KW - Metabolic networking

KW - Rim11

KW - Saccharomyces cerevisiae

KW - Yeast two-hybrid interaction

UR - http://www.scopus.com/inward/record.url?scp=28844495951&partnerID=8YFLogxK

U2 - 10.1042/BST20051418

DO - 10.1042/BST20051418

M3 - Article

C2 - 16246134

VL - 33

SP - 1418

EP - 1420

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 6

ER -

Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae

Abstract

Keywords

Access to Document

Other files and links

Cite this