Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae

S. Vavassori; K. Wang; L. M. Schweizer; M. Schweizer

doi:10.1042/BST20051418

Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae

S. Vavassori, K. Wang, L. M. Schweizer, M. Schweizer

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7 Citations (Scopus)

Abstract

The model eukaryote Saccharomyces cerevisiae is well suited to investigate the causes of metabolic disturbance. PRPP [5-phospho-D-ribosyl-1(a)- pyrophosphate] may be regarded as a junction of carbon and nitrogen metabolism. As a result of this central position, perturbations in its synthesis can give rise to many unexpected cellular events, such as impaired cell integrity. We have taken advantage of S. cerevisiae's genetic tractability to investigate the metabolic links responsible for connecting the biochemical intermediate PRPP to apparently unrelated cellular functions. This approach provides insight into the co-ordination of different biological processes. ©2005 Biochemical Society.

Original language	English
Pages (from-to)	1418-1420
Number of pages	3
Journal	Biochemical Society Transactions
Volume	33
Issue number	6
DOIs	https://doi.org/10.1042/BST20051418
Publication status	Published - Dec 2005

Keywords

5-phospho-D-ribosyl-1(α)- pyrophosphate synthetase (Prs)
Cell integrity
Metabolic networking
Rim11
Saccharomyces cerevisiae
Yeast two-hybrid interaction

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10.1042/BST20051418

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title = "Ramifications of impaired PRPP synthesis in Saccharomyces cerevisiae",

abstract = "The model eukaryote Saccharomyces cerevisiae is well suited to investigate the causes of metabolic disturbance. PRPP [5-phospho-D-ribosyl-1(a)- pyrophosphate] may be regarded as a junction of carbon and nitrogen metabolism. As a result of this central position, perturbations in its synthesis can give rise to many unexpected cellular events, such as impaired cell integrity. We have taken advantage of S. cerevisiae's genetic tractability to investigate the metabolic links responsible for connecting the biochemical intermediate PRPP to apparently unrelated cellular functions. This approach provides insight into the co-ordination of different biological processes. {\textcopyright}2005 Biochemical Society.",

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AU - Vavassori, S.

AU - Wang, K.

AU - Schweizer, L. M.

AU - Schweizer, M.

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KW - Yeast two-hybrid interaction

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