RAFT polymers for protein recognition

Alan F. Tominey; Juila Liese; Sun Wei; Klaus Kowski; Thomas Schrader; Arno Kraft

doi:10.3762/bjoc.6.66

RAFT polymers for protein recognition

Alan F. Tominey, Juila Liese, Sun Wei, Klaus Kowski, Thomas Schrader, Arno Kraft

School of Engineering & Physical Sciences

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Abstract

A new family of linear polymers with pronounced affinity for arginine- and lysine-rich proteins has been created. To this end, N-isopropylacrylamide (NIPAM) was copolymerized in water with a binding monomer and a hydrophobic comonomer using a living radical polymerization (RAFT). The resulting copolymers were water-soluble and displayed narrow polydispersities. They formed tight complexes with basic proteins depending on the nature and amount of the binding monomer as well as on the choice of the added hydrophobic comonomer. © 2010 Tominey et al; licensee Beilstein-Institut.

Original language	English
Article number	66
Journal	Beilstein Journal of Organic Chemistry
Volume	6
DOIs	https://doi.org/10.3762/bjoc.6.66
Publication status	Published - 17 Jun 2010

Keywords

Electrostatic interactions
Hydrophobic effect
Isothermal calorimetry
Protein recognition
RAFT polymers

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title = "RAFT polymers for protein recognition",

abstract = "A new family of linear polymers with pronounced affinity for arginine- and lysine-rich proteins has been created. To this end, N-isopropylacrylamide (NIPAM) was copolymerized in water with a binding monomer and a hydrophobic comonomer using a living radical polymerization (RAFT). The resulting copolymers were water-soluble and displayed narrow polydispersities. They formed tight complexes with basic proteins depending on the nature and amount of the binding monomer as well as on the choice of the added hydrophobic comonomer. {\textcopyright} 2010 Tominey et al; licensee Beilstein-Institut.",

keywords = "Electrostatic interactions, Hydrophobic effect, Isothermal calorimetry, Protein recognition, RAFT polymers",

author = "Tominey, {Alan F.} and Juila Liese and Sun Wei and Klaus Kowski and Thomas Schrader and Arno Kraft",

year = "2010",

month = jun,

day = "17",

doi = "10.3762/bjoc.6.66",

language = "English",

volume = "6",

journal = "Beilstein Journal of Organic Chemistry",

issn = "1860-5397",

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TY - JOUR

T1 - RAFT polymers for protein recognition

AU - Tominey, Alan F.

AU - Liese, Juila

AU - Wei, Sun

AU - Kowski, Klaus

AU - Schrader, Thomas

AU - Kraft, Arno

PY - 2010/6/17

Y1 - 2010/6/17

N2 - A new family of linear polymers with pronounced affinity for arginine- and lysine-rich proteins has been created. To this end, N-isopropylacrylamide (NIPAM) was copolymerized in water with a binding monomer and a hydrophobic comonomer using a living radical polymerization (RAFT). The resulting copolymers were water-soluble and displayed narrow polydispersities. They formed tight complexes with basic proteins depending on the nature and amount of the binding monomer as well as on the choice of the added hydrophobic comonomer. © 2010 Tominey et al; licensee Beilstein-Institut.

AB - A new family of linear polymers with pronounced affinity for arginine- and lysine-rich proteins has been created. To this end, N-isopropylacrylamide (NIPAM) was copolymerized in water with a binding monomer and a hydrophobic comonomer using a living radical polymerization (RAFT). The resulting copolymers were water-soluble and displayed narrow polydispersities. They formed tight complexes with basic proteins depending on the nature and amount of the binding monomer as well as on the choice of the added hydrophobic comonomer. © 2010 Tominey et al; licensee Beilstein-Institut.

KW - Electrostatic interactions

KW - Hydrophobic effect

KW - Isothermal calorimetry

KW - Protein recognition

KW - RAFT polymers

U2 - 10.3762/bjoc.6.66

DO - 10.3762/bjoc.6.66

M3 - Article

SN - 1860-5397

VL - 6

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

M1 - 66

ER -

RAFT polymers for protein recognition

Abstract

Keywords

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