RACK(1) to the future – a historical perspective

Dorit Ron; Dave Adams; George S Baillie; Aideen Long; Rosemary O'Connor; Patrick A Kiely

doi:10.1186/1478-811X-11-53

RACK(1) to the future – a historical perspective

Dorit Ron, Dave Adams, George S Baillie, Aideen Long, Rosemary O'Connor, Patrick A Kiely

Research output: Contribution to journal › Comment/debate › peer-review

29 Citations (Scopus)

140 Downloads (Pure)

Abstract

This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1’s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.

Original language	English
Article number	53
Number of pages	4
Journal	Cell Communication and Signaling
Volume	11
DOIs	https://doi.org/10.1186/1478-811X-11-53
Publication status	Published - 1 Aug 2013

Keywords

PROTEIN-KINASE-C
CELL-MIGRATION
SUBSTRATE RECOGNITION
ACTIVATED C-KINASE-1
BETA
RECEPTOR
TRANSLATION
ADHESION
SCAFFOLD
BINDING

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "RACK(1) to the future – a historical perspective",

abstract = "This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1{\textquoteright}s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.",

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AU - O'Connor, Rosemary

AU - Kiely, Patrick A

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AB - This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1’s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.

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KW - CELL-MIGRATION

KW - SUBSTRATE RECOGNITION

KW - ACTIVATED C-KINASE-1

KW - BETA

KW - RECEPTOR

KW - TRANSLATION

KW - ADHESION

KW - SCAFFOLD

KW - BINDING

U2 - 10.1186/1478-811X-11-53

DO - 10.1186/1478-811X-11-53

M3 - Comment/debate

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SN - 1478-811X

VL - 11

JO - Cell Communication and Signaling

JF - Cell Communication and Signaling

M1 - 53

ER -

RACK(1) to the future – a historical perspective

Abstract

Keywords

UN SDGs

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