Quinolin-2(1H)-one-triazole derived Schiff bases and their Cu(II) and Zn(II) complexes: Possible new therapeutic agents

Bernadette S. Creaven, Michael Devereux, Agnieszka Foltyn, Siobhán McClean, Georgina Rosair, Venkat Reddy Thangella, Maureen Walsh

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82 Citations (Scopus)


The condensation of 4-amino-1,2,4-triazole with N-substituted-3-formyl-4-hydroxyquinolin-2-(1H)-one derivatives has lead to the synthesis of a new series of quinolin-2(1H)-one-triazole derived Schiff base ligands (1-3). Cu(II) and Zn(II) complexes (1a-3a and 1b-3b, respectively) of these ligands were also prepared. The complexes were characterised by standard techniques and for two of the complexes X-ray crystallography confirmed that the geometry at the metal centre was octahedral in both cases and that the Schiff base acted as a bidentate ligand coordinating to the metal(II) ion through the deprotonated oxygen and azomethine nitrogen atoms. All of the compounds were investigated for their antimicrobial activities against a fungal strain, Candida albicans, and against Gram-positive and Gram-negative bacteria. The compounds were found to be active against C. albicans but inactive against Staphylococcus aureus and Escherichia coli. © 2009 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)813-822
Number of pages10
Issue number2
Publication statusPublished - 1 Feb 2010


  • 4-Amino-1,2,4-triazole
  • Biological activity
  • Metal(II) complexes
  • Quinolin-2(1H)-one
  • Schiff bases
  • X-ray structures


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