TY - JOUR
T1 - Quinolin-2(1H)-one-triazole derived Schiff bases and their Cu(II) and Zn(II) complexes
T2 - Possible new therapeutic agents
AU - Creaven, Bernadette S.
AU - Devereux, Michael
AU - Foltyn, Agnieszka
AU - McClean, Siobhán
AU - Rosair, Georgina
AU - Thangella, Venkat Reddy
AU - Walsh, Maureen
PY - 2010/2/1
Y1 - 2010/2/1
N2 - The condensation of 4-amino-1,2,4-triazole with N-substituted-3-formyl-4-hydroxyquinolin-2-(1H)-one derivatives has lead to the synthesis of a new series of quinolin-2(1H)-one-triazole derived Schiff base ligands (1-3). Cu(II) and Zn(II) complexes (1a-3a and 1b-3b, respectively) of these ligands were also prepared. The complexes were characterised by standard techniques and for two of the complexes X-ray crystallography confirmed that the geometry at the metal centre was octahedral in both cases and that the Schiff base acted as a bidentate ligand coordinating to the metal(II) ion through the deprotonated oxygen and azomethine nitrogen atoms. All of the compounds were investigated for their antimicrobial activities against a fungal strain, Candida albicans, and against Gram-positive and Gram-negative bacteria. The compounds were found to be active against C. albicans but inactive against Staphylococcus aureus and Escherichia coli. © 2009 Elsevier Ltd. All rights reserved.
AB - The condensation of 4-amino-1,2,4-triazole with N-substituted-3-formyl-4-hydroxyquinolin-2-(1H)-one derivatives has lead to the synthesis of a new series of quinolin-2(1H)-one-triazole derived Schiff base ligands (1-3). Cu(II) and Zn(II) complexes (1a-3a and 1b-3b, respectively) of these ligands were also prepared. The complexes were characterised by standard techniques and for two of the complexes X-ray crystallography confirmed that the geometry at the metal centre was octahedral in both cases and that the Schiff base acted as a bidentate ligand coordinating to the metal(II) ion through the deprotonated oxygen and azomethine nitrogen atoms. All of the compounds were investigated for their antimicrobial activities against a fungal strain, Candida albicans, and against Gram-positive and Gram-negative bacteria. The compounds were found to be active against C. albicans but inactive against Staphylococcus aureus and Escherichia coli. © 2009 Elsevier Ltd. All rights reserved.
KW - 4-Amino-1,2,4-triazole
KW - Biological activity
KW - Metal(II) complexes
KW - Quinolin-2(1H)-one
KW - Schiff bases
KW - X-ray structures
UR - http://www.scopus.com/inward/record.url?scp=73649099914&partnerID=8YFLogxK
U2 - 10.1016/j.poly.2009.11.002
DO - 10.1016/j.poly.2009.11.002
M3 - Article
SN - 0277-5387
VL - 29
SP - 813
EP - 822
JO - Polyhedron
JF - Polyhedron
IS - 2
ER -