Quinolin-2(1H)-one-triazole derived Schiff bases and their Cu(II) and Zn(II) complexes: Possible new therapeutic agents

Bernadette S. Creaven, Michael Devereux, Agnieszka Foltyn, Siobhán McClean, Georgina Rosair, Venkat Reddy Thangella, Maureen Walsh

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The condensation of 4-amino-1,2,4-triazole with N-substituted-3-formyl-4-hydroxyquinolin-2-(1H)-one derivatives has lead to the synthesis of a new series of quinolin-2(1H)-one-triazole derived Schiff base ligands (1-3). Cu(II) and Zn(II) complexes (1a-3a and 1b-3b, respectively) of these ligands were also prepared. The complexes were characterised by standard techniques and for two of the complexes X-ray crystallography confirmed that the geometry at the metal centre was octahedral in both cases and that the Schiff base acted as a bidentate ligand coordinating to the metal(II) ion through the deprotonated oxygen and azomethine nitrogen atoms. All of the compounds were investigated for their antimicrobial activities against a fungal strain, Candida albicans, and against Gram-positive and Gram-negative bacteria. The compounds were found to be active against C. albicans but inactive against Staphylococcus aureus and Escherichia coli. © 2009 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)813-822
Number of pages10
JournalPolyhedron
Volume29
Issue number2
DOIs
Publication statusPublished - 1 Feb 2010

Keywords

  • 4-Amino-1,2,4-triazole
  • Biological activity
  • Metal(II) complexes
  • Quinolin-2(1H)-one
  • Schiff bases
  • X-ray structures

Fingerprint Dive into the research topics of 'Quinolin-2(1H)-one-triazole derived Schiff bases and their Cu(II) and Zn(II) complexes: Possible new therapeutic agents'. Together they form a unique fingerprint.

  • Cite this

    Creaven, B. S., Devereux, M., Foltyn, A., McClean, S., Rosair, G., Thangella, V. R., & Walsh, M. (2010). Quinolin-2(1H)-one-triazole derived Schiff bases and their Cu(II) and Zn(II) complexes: Possible new therapeutic agents. Polyhedron, 29(2), 813-822. https://doi.org/10.1016/j.poly.2009.11.002