Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives

Danail Hristozov*, Lisa Pizzol, Gianpietro Basei, Alex Zabeo, Aiga Mackevica, Steffen Foss Hansen, Ilse Gosens, Flemming R. Cassee, Wim de Jong, Antti Joonas Koivisto, Nicole Neubauer, Araceli Sanchez Jimenez, Elena Semenzin, Vrishali Subramanian, Wouter Fransman, Keld Alstrup Jensen, Wendel Wohlleben, Vicki Stone, Antonio Marcomini

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


The use of nano-scale copper oxide (CuO) and basic copper carbonate (Cu2(OH)2CO3) in both ionic and micronized wood preservatives has raised concerns about the potential of these substances to cause adverse humans health effects. To address these concerns, we performed quantitative (probabilistic) human health risk assessment (HHRA) along the lifecycles of these formulations used in antibacterial and antifungal wood coatings and impregnations by means of the EU FP7 SUN project’s Decision Support System (SUNDS, www.sunds.gd). The results from the risk analysis revealed inhalation risks from CuO in exposure scenarios involving workers handling dry powders and performing sanding operations as well as potential ingestion risks for children exposed to nano Cu2(OH)2CO3 in a scenario involving hand-to-mouth transfer of the substance released from impregnated wood. There are, however, substantial uncertainties in these results, so some of the identified risks may stem from the safety margin of extrapolation to fill data gaps and might be resolved by additional testing. Our stochastic approach successfully communicated the contribution of different sources of uncertainty in the risk assessment. The main source of uncertainty was the extrapolation from short to long-term exposure, which was necessary due to the lack of (sub)chronic in vivo studies with CuO and Cu2(OH)2CO3. Considerable uncertainties also stemmed from the use of default inter- and intra-species extrapolation factors.

Original languageEnglish
Pages (from-to)747-765
Number of pages19
Issue number7
Early online date12 Jun 2018
Publication statusPublished - 9 Aug 2018


  • copper carbonate
  • copper oxide
  • Engineered nanomaterials
  • probabilistic human health risk assessment
  • SUN Decision Support System

ASJC Scopus subject areas

  • Biomedical Engineering
  • Toxicology


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