Quantitative diagnostics of soft tissue through viscoelastic characterization using time-based instrumented palpation

Javier Palacio Torralba, Steven J Hammer, Daniel W Good, Alan S McNeill, Grant D Stewart, Robert Lewis Reuben, Yuhang Chen

Research output: Contribution to journalArticle

34 Citations (Scopus)
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Abstract

Although palpation has been successfully employed for centuries to assess soft tissue quality, it is a subjective test, and is therefore qualitative and depends on the experience of the practitioner. To reproduce what the medical practitioner feels needs more than a simple quasi-static stiffness measurement. This paper assesses the capacity of dynamic mechanical palpation to measure the changes in viscoelastic properties that soft tissue can exhibit under certain pathological conditions. A diagnostic framework is proposed to measure elastic and viscous behaviors simultaneously using a reduced set of viscoelastic parameters, giving a reliable index for quantitative assessment of tissue quality, The approach is illustrated on prostate models reconstructed from prostate MRI scans. The examples show that the change in viscoelastic time constant between healthy and cancerous tissue is a key index for quantitative diagnostics using point probing. The method is not limited to any particular tissue or material and is therefore useful for tissue where defining a unique time constant is not trivial. The proposed framework of quantitative assessment could become a useful tool in clinical diagnostics for soft tissue. (C) 2014 The Authors. Published by Elsevier Ltd.

Original languageEnglish
Pages (from-to)149-160
Number of pages12
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume41
Early online date1 Nov 2014
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Tissue mechanics
  • Tissue diagnostics
  • Viscoelasticity
  • Soft tissue
  • Quantitative diagnostics
  • MECHANICAL PROPERTY CHARACTERIZATION
  • FIBER-REINFORCED COMPOSITES
  • IN-VIVO
  • MR ELASTOGRAPHY
  • PROSTATE-CANCER
  • CONSTITUTIVE MODELS
  • ROBOTIC PALPATION
  • CONTINUUM BASIS
  • FINITE STRAINS
  • BEHAVIOR

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